ReviewReproductive medicine and biology
The roles of sex hormones in the pathophysiology of age-related sarcopenia and frailty.
Review in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 31 citations in OpenAlex.
- Evaluation of the fracture prevention effects of teriparatide and alendronate in patients with frailty: a sub-analysis of the Japanese osteoporosis intervention trial-05.Journal of bone and mineral metabolism · 2025Trial
- Sex-Specific Differences in Patients with Sarcopenia and Peripheral Artery Disease.Muscles (Basel, Switzerland) · 2026Article
- Revitalizing Muscles: Harnessing Exercise to Modulate Inflammatory Cytokines and Conquer Sarcopenia in Aging.Cell biochemistry and biophysics · 2026Review
- Rethinking nutritional risk in cancer: muscle quality, myosteatosis, and prognosis.Hepatobiliary surgery and nutrition · 2026Article
- Nationwide survey of Japanese Physicians on Kampo medicine use in frailty care.Scientific reports · 2026Article
- Automated CT-Based Muscle Density Predicts Mortality Regardless of Muscle Area.Journal of cachexia, sarcopenia and muscle · 2026Article
- Care for deficits in activities of daily living (ADL) and instrumental ADL and unmet care needs among Austrians aged 65 and over.Wiener medizinische Wochenschrift (1946) · 2026Article
- A Cross-Sectional Analysis of Musculoskeletal and Functional Outcomes in Patients with Pituitary Disorders: Frailty and Sarcopenia.Journal of clinical medicine · 2026Article
- Longitudinal study on the relationship between extracellular water distribution changes and muscle mass in severe sarcopenia patients using multi-frequency bioelectrical impedance analysis combined with phase angle measurements.European geriatric medicine · 2026Article
- The Effects of Gamified Virtual Reality on Muscle Strength and Physical Function in the Oldest Old-A Pilot Study on Sarcopenia-Related Functional Outcomes.Journal of clinical medicine · 2026Article
- Sarcopenia risk in women with postmenopausal osteoporosis: a SARC-F-based assessment.Turkish journal of medical sciences · 2026Article
- Accelerated biological aging and risk of sarcopenia: evidence from 29,000 Chinese adults.Biology of sport · 2026Article
- Development and validation of a machine learning-based risk prediction model for sarcopenia in community hospital patients: a retrospective cohort study.Frontiers in aging · 2026Article
- Ultrasound-assessed abdominal fat distribution and its relation to sarcopenia parameters in community-dwelling young older adults: a cross-sectional study.Frontiers in endocrinology · 2026Observational
- Sarcopenia in the Aging Process: Pathophysiological Mechanisms, Clinical Implications, and Emerging Therapeutic Approaches.International journal of molecular sciences · 2025Review
- Skeletal Muscle-Cardiac Muscle Aging: Shared Mechanisms and Multimodal Interventions.JACC. Advances · 2025Review
- Dynapenia, Dehydroepiandrosterone (DHEA), and Redox Balance in Geriatric Patients-Does Sex Play a Role?Nutrients · 2025Article
- Exploring the link between osteosarcopenia and osteoarthritis in prediabetic adults using NHANES data.Scientific reports · 2025Article
- Preventative approaches to falls and frailty.Osteoporosis and sarcopenia · 2025Review
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sarcopenia is an age-related condition characterized by a progressive and systemic decline in skeletal muscle mass, quality, and strength. The incidence of sarcopenia contains sex-specific aspects, indicating the contribution of sex hormones to its pathophysiology. This review focuses on changing trends in sarcopenia, discusses alterations in definitions and diagnostic criteria, and emphasizes the association between sarcopenia and sex hormones. Methods: A literature search was performed on PubMed for related articles published between 1997 and December 2023 using appropriate keywords. Main Findings Results: Advances in research have emphasized the significance of muscle quality and strength over muscle mass, resulting in new diagnostic criteria for sarcopenia. Androgens demonstrated anabolic effects on skeletal muscles and played a significant role in the pathophysiology of sarcopenia. In clinical settings, androgen replacement therapy has exhibited certain positive outcomes for treating sarcopenia, despite concerns about potential side effects. Conversely, estrogen is involved in skeletal muscle maintenance, but the detailed mechanisms remain unclear. Moreover, results regarding the clinical application of estrogen replacement therapy for treating sarcopenia remained inconsistent. Conclusion: The elucidation of molecular mechanisms that involve sex hormones is eagerly awaited for novel therapeutic interventions for sarcopenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.