Evidence map›Paper›PMID 38476661›Full record

ReviewFrontiers in aging neuroscience2024

Transcutaneous vagus nerve stimulation: a new strategy for Alzheimer's disease intervention through the brain-gut-microbiota axis?

Long Yan, Hong Li, Yulin Qian, Junfeng Zhang, Shan Cong, Xuemin Zhang, Linna Wu, Yu Wang, Meng Wang, Tao Yu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
7.7field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Long YanThe First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Hong LiThe First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Yulin QianThe First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Junfeng ZhangThe First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Shan CongThe First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Xuemin ZhangGraduate Department, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Linna WuGraduate Department, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Yu WangThe First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Meng WangThe First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Tao YuThe First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine · CNTianjin University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcutaneous vagus nerve stimulation (tVNS) is an emerging non-invasive technique designed to stimulate branches of the vagus nerve distributed over the body surface. Studies suggest a correlation between the brain-gut-microbiota (BGM) axis and the pathogenesis of Alzheimer's disease (AD). The BGM axis represents a complex bidirectional communication system, with the vagus nerve being a crucial component. Therefore, non-invasive electrical stimulation of the vagus nerve might have the potential to modify-most of the time probably in a non-physiological way-the signal transmission within the BGM axis, potentially influencing the progression or symptoms of AD. This review explores the interaction between percutaneous vagus nerve stimulation and the BGM axis, emphasizing its potential effects on AD. It examines various aspects, such as specific brain regions, gut microbiota composition, maintenance of intestinal environmental homeostasis, inflammatory responses, brain plasticity, and hypothalamic-pituitary-adrenal (HPA) axis regulation. The review suggests that tVNS could serve as an effective strategy to modulate the BGM axis and potentially intervene in the progression or treatment of Alzheimer's disease in the future.

Indexed as

Alzheimer’s diseasebrain-gut-microbiota axisHPA axismicrobiotatranscutaneous vagus nerve stimulation

Identifiers

PMID38476661
PMCPMC10927744
OpenAlexW4392195768

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.