ArticleWorld journal of emergency medicine2024
Impact of next-generation sequencing on antimicrobial treatment in immunocompromised adults with suspected infections.
Article in World journal of emergency medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Odontogenic liver abscess in one patient.World journal of emergency medicine · 2026Article
- Glucocorticoid-mediated suppression of the CCL2-CCR2 axis drives monocyte dysfunction in severe pneumonia among immunocompromised hosts.Respiratory research · 2025Article
- Pneumonia with parapneumonic effusion due toWorld journal of emergency medicine · 2025Article
- Life-threatening gastrointestinal bleeding in a rare case of blue rubber bleb nevus syndrome.World journal of emergency medicine · 2025Article
- Impact of metagenomics next-generation sequencing on etiological diagnosis and early outcomes in sepsis.Journal of translational medicine · 2025Article
- The Adequacy of Current Legionnaires' Disease Diagnostic Practices in Capturing the Epidemiology of Clinically RelevantPathogens (Basel, Switzerland) · 2024Article
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Authors and funding
6 authors.
Funding
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Abstract
backgroundPrompt pathogen identification can have a substantial impact on the optimization of antimicrobial treatment. The objective of the study was to assess the diagnostic value of next-generation sequencing (NGS) for identifying pathogen and its clinical impact on antimicrobial intervention in immunocompromised patients with suspected infections.
methodsThis was a retrospective study. Between January and August 2020, 47 adult immunocompromised patients underwent NGS testing under the following clinical conditions: 1) prolonged fever and negative conventional cultures; 2) new-onset fever despite empiric antimicrobial treatment; and 3) afebrile with suspected infections on imaging. Clinical data, including conventional microbial test results and antimicrobial treatment before and after NGS, were collected. Data were analyzed according to documented changes in antimicrobial treatment (escalated, no change, or de-escalated) after the NGS results.
resultsThe median time from hospitalization to NGS sampling was 19 d. Clinically relevant pathogens were detected via NGS in 61.7% of patients (29/47), more than half of whom suffered from fungemia (
conclusionWith its rapid identification and high sensitivity, NGS could be a promising tool for identifying relevant pathogens and enabling rapid appropriate treatment in immunocompromised patients with suspected infections.
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