ArticleProgress in polymer science2024
Structural Determinants of Stimuli-Responsiveness in Amphiphilic Macromolecular Nano-assemblies.
Article in Progress in polymer science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Dual Acidic pH-Responsive Post-Crosslinked E-Spun Nanofibrous Scaffolds Exhibiting Enhanced Disassembly and Release for Localized Cancer Treatment.Advanced healthcare materials · 2026Article
- Supramolecular Assemblies of Self-Immolative Janus Dendrimers With Rapid Photodegradation Response.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Smart Nanomedicines for Neurodegenerative Diseases: Empowering New Therapies with Molecular Imaging and Artificial Intelligence.Molecular diagnosis & therapy · 2026Review
- Enhanced separation and purification of vanillin in aqueous-phase through specific Achiff base covalent imprinting.Mikrochimica acta · 2025Article
- Unimer Exchange as a Tool for Programming Enzymatic Degradation through Micellar Dynamics.Biomacromolecules · 2025Article
- Stability of Acetals/Ketals Under Controlled Radical and Ring Opening Polymerization.Macromolecular rapid communications · 2025Article
- Polymersome-based nanomotors: preparation, motion control, and biomedical applications.Chemical science · 2025Review
- Molecular-Based Nanoplatform Leads to the Formation of a Self-Indicating Responsive Drug Delivery System.Molecules (Basel, Switzerland) · 2025Article
- Article
- Antibody-Directing Antibody Conjugates (ADACs) Enabled by Orthogonal Click Chemistry for Targeted Intracellular Delivery.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Strategies, Challenges, and Prospects of Nanoparticles in Gynecological Malignancies.ACS omega · 2024Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Stimuli-responsive nano-assemblies from amphiphilic macromolecules could undergo controlled structural transformations and generate diverse macroscopic phenomenon under stimuli. Due to the controllable responsiveness, they have been applied for broad material and biomedical applications, such as biologics delivery, sensing, imaging, and catalysis. Understanding the mechanisms of the assembly-disassembly processes and structural determinants behind the responsive properties is fundamentally important for designing the next generation of nano-assemblies with programmable responsiveness. In this review, we focus on structural determinants of assemblies from amphiphilic macromolecules and their macromolecular level alterations under stimuli, such as the disruption of hydrophilic-lipophilic balance (HLB), depolymerization, decrosslinking, and changes of molecular packing in assemblies, which eventually lead to a series of macroscopic phenomenon for practical purposes. Applications of stimuli-responsive nano-assemblies in delivery, sensing and imaging were also summarized based on their structural features. We expect this review could provide readers an overview of the structural considerations in the design and applications of nanoassemblies and incentivize more explorations in stimuli-responsive soft matters.
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Registered trials
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