Evidence map›Paper›PMID 38476146›Full record

ArticleFrontiers in physiology2024

Microglial reactivity in brainstem chemosensory nuclei in response to hypercapnia.

Jaime Eugenín, Sebastián Beltrán-Castillo, Estefanía Irribarra, Raúl Pulgar-Sepúlveda, Nicolás Abarca, Rommy von Bernhardi

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. The Central Role of Macrophages in Long COVID Pathophysiology.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jaime EugenínFacultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.
Sebastián Beltrán-CastilloFacultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.
Estefanía IrribarraFacultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.
Raúl Pulgar-SepúlvedaFacultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.
Nicolás AbarcaFacultad de Química y Biología, Universidad de Santiago de Chile, Santiago, Chile.
Rommy von BernhardiFacultad de Odontología y Ciencias de la Rehabilitación, Universidad San Sebastián, Santiago, Chile.
Universidad de Santiago de Chile · CLSan Sebastián University · CLUniversidad Bernardo O'Higgins · CL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia, the resident immune cells of the CNS, surveil, detect, and respond to various extracellular signals. Depending on the nature of these signals, an integrative microglial response can be triggered, resulting in a phenotypic transformation. Here, we evaluate whether hypercapnia modifies microglia phenotype in brainstem respiratory-related nuclei. Adult C57BL/6 inbred mice were exposed to 10% CO

Indexed as

CD206CD86hypercapniainflammatory functional stateinterleukin 1βmicrogliaTGFβ

Identifiers

PMID38476146
PMCPMC10927973
OpenAlexW4392196564

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.