ArticleJournal of periodontology2024
Evaluation of microbiome in primary and permanent dentition in grade C periodontitis in young individuals.
Article in Journal of periodontology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- Periodontitis and Periodontal Conditions in Systemically Healthy Children and Adolescents.Journal of clinical periodontology · 2026Review
- The Evolution of Prepubertal Localized Aggressive Periodontitis in Primary and Mixed Dentition-Clinical Evidence.Journal of clinical medicine · 2026Article
- Peridontopathogenic key species in correlation to the current classification system.Clinical oral investigations · 2025Article
- Human Herpesviruses, Bacteria, and Fungi in Gingivitis and Periodontitis Pediatric Subjects: A Systematic Review.Children (Basel, Switzerland) · 2024Review
- A Rose by Any Other Name: The Long Intricate History of Localized Aggressive Periodontitis.Pathogens (Basel, Switzerland) · 2024Review
- From Global to Nano: A Geographical Perspective ofPathogens (Basel, Switzerland) · 2024Review
- Grade C Molar-Incisor Pattern Periodontitis in Young Adults: What Have We Learned So Far?Pathogens (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundThe aim of the present study was to evaluate the subgingival microbiome in patients with grade C molar-incisor pattern periodontitis (C-MIP) affecting the primary or permanent dentitions.
methodsDNA was isolated from subgingival biofilm samples from diseased and healthy sites from 45 C-MIP patients and subjected to phylogenetic microarray analysis. C-MIP sites were compared between children affected in the primary to those affected in the permanent dentitions. Within-subject differences between C-MIP-affected sites and dentition-matched healthy sites were also evaluated.
resultsC-MIP sites of subjects affected in the primary dentition showed partially overlapping but distinct microbial communities from C-MIP permanent dentition sites (p < 0.05). Differences were due to increased levels in primary C-MIP sites of certain species of the genera Capnocytophaga and Leptotrichia, while C-MIP permanent dentition sites showed higher prevalence of Filifactor alocis. Aggregatibacter actinomycetemcomitans (Aa) was among species seen in high prevalence and levels in both primary and permanent C-MIP sites. Moreover, both permanent and primary C-MIP sites showed distinct microbial communities when compared to dentition-matched healthy sites in the same subject (p < 0.01).
conclusionsPrimary and permanent teeth with C-MIP showed a dysbiotic microbiome, with children affected in the primary dentition showing a distinct profile from those affected in the permanent dentition. However, Aa was enriched in both primary and permanent diseased sites, confirming that this microorganism is implicated in C-MIP in both dentitions.
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