Evidence map›Paper›PMID 38476042›Full record

ArticleThe American journal of psychiatry2024

Sex-Specific Distributed White Matter Microarchitectural Alterations in Preadolescent Youths With Anxiety Disorders: A Mega-Analytic Study.

Nakul Aggarwal, Do P M Tromp, Jennifer U Blackford, Daniel S Pine, Patrick H Roseboom, Lisa E Williams, Ned H Kalin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Nakul AggarwalDepartment of Psychiatry, University of Wisconsin-Madison (Aggarwal, Tromp, Roseboom, Williams, Kalin); Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha (Blackford); Section on Developmental and Affective Neuroscience, NIMH, Bethesda, Md. (Pine).
Do P M TrompDepartment of Psychiatry, University of Wisconsin-Madison (Aggarwal, Tromp, Roseboom, Williams, Kalin); Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha (Blackford); Section on Developmental and Affective Neuroscience, NIMH, Bethesda, Md. (Pine).
Jennifer U BlackfordDepartment of Psychiatry, University of Wisconsin-Madison (Aggarwal, Tromp, Roseboom, Williams, Kalin); Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha (Blackford); Section on Developmental and Affective Neuroscience, NIMH, Bethesda, Md. (Pine).
Daniel S PineDepartment of Psychiatry, University of Wisconsin-Madison (Aggarwal, Tromp, Roseboom, Williams, Kalin); Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha (Blackford); Section on Developmental and Affective Neuroscience, NIMH, Bethesda, Md. (Pine).
Patrick H RoseboomDepartment of Psychiatry, University of Wisconsin-Madison (Aggarwal, Tromp, Roseboom, Williams, Kalin); Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha (Blackford); Section on Developmental and Affective Neuroscience, NIMH, Bethesda, Md. (Pine).
Lisa E WilliamsDepartment of Psychiatry, University of Wisconsin-Madison (Aggarwal, Tromp, Roseboom, Williams, Kalin); Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha (Blackford); Section on Developmental and Affective Neuroscience, NIMH, Bethesda, Md. (Pine).
Ned H KalinDepartment of Psychiatry, University of Wisconsin-Madison (Aggarwal, Tromp, Roseboom, Williams, Kalin); Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha (Blackford); Section on Developmental and Affective Neuroscience, NIMH, Bethesda, Md. (Pine).
Nebraska Medical Center · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
fMRI Studies Of Pediatric Mood And Anxiety DisordersZIAMH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2009 to 2025
$41.5M
TRAINING PROGRAM IN EMOTION RESEARCHT32MH018931 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Richard J Davidson · 1989 to 2026
$11.6M
Integrated Training For Physician-ScientistsT32GM140935 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anna Huttenlocher, Jeniel E Nett · 2021 to 2026
$6.5M
Extreme anxiety in females: The role of the bed nucleus of the stria terminalis (BST) during the transition to adolescence in human and nonhuman primatesR01MH107563 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI KALIN, NED H · 2015 to 2019
$3.5M
Studies to understand the pathophysiology of childhood anxiety disordersU01MH112913 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKFORD, JENNIFER URBANO, KALIN, NED H · 2018 to 2022
$3.4M
Fmri Studies Of Pediatric Mood And Anxiety DisordersZ01MH002781 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PINE, DANIEL · 2002 to 2008
$1.5M
Brain Mechanisms Underlying Childhood Generalized Anxiety DisorderR21MH092581 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI KALIN, NED H · 2012 to 2013
$405k
Intramural NIH HHS Z01 MH002781Intramural NIH HHS ZIA MH002781NCATS NIH HHS UL1 TR002373NIGMS NIH HHS T32 GM140935NIMH NIH HHS R01 MH107563NIMH NIH HHS R21 MH092581NIMH NIH HHS T32 MH018931NIMH NIH HHS U01 MH112913
6 · The paper itself

Abstract

objectiveAnxiety disorders are among the most common psychiatric disorders in youths and emerge during childhood. This is also a period of rapid white matter (WM) development, which is critical for efficient neuronal communication. Previous work in preadolescent children with anxiety disorders demonstrated anxiety disorder-related reductions in WM microstructural integrity (fractional anisotropy [FA]) in the uncinate fasciculus (UF), the major WM tract facilitating prefrontal cortical-limbic structural connectivity. Importantly, this association was found only in boys with anxiety disorders. To confirm this finding and more comprehensively understand WM changes in childhood anxiety, this mega-analytic study characterizes WM alterations related to anxiety disorders and sex in the largest sample of preadolescent children to date.

methodsDiffusion tensor imaging data from published studies of preadolescent children with anxiety disorders and healthy volunteers (ages 8-12) (N=198) were combined with a new data set (N=97) for a total sample of 165 children with anxiety disorders and 132 healthy volunteers. Children with anxiety disorders met DSM-5 criteria for current generalized, separation, and/or social anxiety disorder. Analyses of tractography and voxel-wise data assessed between-group differences (anxiety disorder vs. healthy volunteer), effects of sex, and their interaction.

resultsTract-based and voxel-wise analyses confirmed a significant reduction in UF FA in boys but not girls with anxiety disorders. Results also demonstrated other significant widespread anxiety disorder-related WM alterations specifically in boys, including in multiple commissural, association, projection, and brainstem regions.

conclusionsIn addition to confirming male-specific anxiety disorder-related reductions in UF FA, the results demonstrate that anxiety disorders in boys and not girls are associated with broadly distributed WM alterations across the brain. These findings support further studies focused on understanding the extent to which WM alterations in boys with anxiety disorders are involved in pathophysiological processes that mediate anxiety disorders. The findings also suggest the possibility that WM microarchitecture could serve as a novel treatment target for childhood anxiety disorders.

Indexed as

White MatterAdolescentAnisotropyAnxiety DisordersBrainChildDiffusion Tensor ImagingFemaleHumansMalePrefrontal CortexAnxiety DisordersChild/Adolescent PsychiatryGender DifferencesNeuroimaging

Identifiers

PMID38476042
PMCPMC11129321
OpenAlexW4392753225

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.