ArticleInfectious diseases of poverty2024
Natural variables separate the endemic areas of Clonorchis sinensis and Opisthorchis viverrini along a continuous, straight zone in Southeast Asia.
Article in Infectious diseases of poverty, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 9 citations in OpenAlex.
- Assessing the risk of malaria re-transmission in Anhui Province, China: an integration of spatiotemporal scan statistics and ecological niche modeling.BMC infectious diseases · 2026Article
- Determinants of preventive behaviors against liver fluke and cholangiocarcinoma in Laos: A TPB-based cross-sectional study.Journal of education and health promotion · 2026Article
- Consumption of raw or undercooked freshwater fish and awareness of risks of associated bacterial and parasitic infections in Southeast Asia: an online multicountry cross-sectional survey.BMJ public health · 2026Article
- CagA-positive Helicobacter pylori may be associated with current infection of clonorchiasis.Scientific reports · 2025Article
- Ecological epidemiology insights into clonorchiosis endemicity in Guangxi, China and Vietnam: a comprehensive machine learning analysis.International journal of health geographics · 2025Article
- Epidemiology and risk factors of Clonorchis sinensis infection in the mountainous areas of Longsheng County, Guangxi: insights from automated machine learning.Parasitology research · 2025Article
- Global, regional and national disease burden of food-borne trematodiases: projections to 2030 based on the Global Burden of Disease Study 2021.Infectious diseases of poverty · 2024Article
- Social Determinants of Health Associated with Cholangiocarcinoma Risk in High-Risk Areas of Thailand: A Case-Control Study.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Risk factors of cholangiocarcinoma: more than control of liver fluke.Asian biomedicine : research, reviews and news · 2024Article
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10 authors at 6 institutions in 6 countries.
Funding
Abstract
backgroundClonorchiasis and opisthorchiasis, caused by the liver flukes Clonorchis sinensis and Opisthorchis viverrini respectively, represent significant neglected tropical diseases (NTDs) in Asia. The co-existence of these pathogens in overlapping regions complicates effective disease control strategies. This study aimed to clarify the distribution and interaction of these diseases within Southeast Asia.
methodsWe systematically collated occurrence records of human clonorchiasis (n = 1809) and opisthorchiasis (n = 731) across the Southeast Asia countries. Utilizing species distribution models incorporating environmental and climatic data, coupled machine learning algorithms with boosted regression trees, we predicted and distinguished endemic areas for each fluke species. Machine learning techniques, including geospatial analysis, were employed to delineate the boundaries between these flukes.
resultsOur analysis revealed that the endemic range of C. sinensis and O. viverrini in Southeast Asia primarily spans across part of China, Vietnam, Thailand, Laos, and Cambodia. During the period from 2000 to 2018, we identified C. sinensis infections in 84 distinct locations, predominantly in southern China (Guangxi Zhuang Autonomous Region) and northern Vietnam. In a stark contrast, O. viverrini was more widely distributed, with infections documented in 721 locations across Thailand, Laos, Cambodia, and Vietnam. Critical environmental determinants were quantitatively analyzed, revealing annual mean temperatures ranging between 14 and 20 °C in clonorchiasis-endemic areas and 24-30 °C in opisthorchiasis regions (P < 0.05). The machine learning model effectively mapped a distinct demarcation zone, demonstrating a clear separation between the endemic areas of these two liver flukes with AUC from 0.9 to1. The study in Vietnam delineates the coexistence and geographical boundaries of C. sinensis and O. viverrini, revealing distinct endemic zones and a transitional area where both liver fluke species overlap.
conclusionsOur findings highlight the critical role of specific climatic and environmental factors in influencing the geographical distribution of C. sinensis and O. viverrini. This spatial delineation offers valuable insights for integrated surveillance and control strategies, particularly in regions with sympatric transmission. The results underscore the need for tailored interventions, considering regional epidemiological variations. Future collaborations integrating eco-epidemiology, molecular epidemiology, and parasitology are essential to further elucidate the complex interplay of liver fluke distributions in Asia.
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