Evidence map›Paper›PMID 38475896›Full record

ArticleStem cell research & therapy2024

Short cell cycle duration is a phenotype of human epidermal stem cells.

Tong Xiao, Ugomma C Eze, Alex Charruyer-Reinwald, Tracy Weisenberger, Ayman Khalifa, Brook Abegaze, Gabrielle K Schwab, Rasha H Elsabagh, T Richard Parenteau, Karl Kochanowski and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 3 countries.

Tong XiaoDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Ugomma C EzeDepartment of Dermatology, San Francisco Co-Director Epithelial Section Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, 1700 Owens Street, San Francisco, CA, 94158, USA.
Alex Charruyer-ReinwaldDepartment of Dermatology, San Francisco Co-Director Epithelial Section Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, 1700 Owens Street, San Francisco, CA, 94158, USA.
Tracy WeisenbergerDepartment of Dermatology, San Francisco Co-Director Epithelial Section Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, 1700 Owens Street, San Francisco, CA, 94158, USA.
Ayman KhalifaDepartment of Dermatology, San Francisco Co-Director Epithelial Section Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, 1700 Owens Street, San Francisco, CA, 94158, USA.
Brook AbegazeDepartment of Dermatology, San Francisco Co-Director Epithelial Section Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, 1700 Owens Street, San Francisco, CA, 94158, USA.
Gabrielle K SchwabDepartment of Dermatology, San Francisco Co-Director Epithelial Section Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, 1700 Owens Street, San Francisco, CA, 94158, USA.
Rasha H ElsabaghImmunology Department, Animal Health Research Institute (AHRI), Giza, Egypt.
T Richard ParenteauDivision of Geriatrics, UC San Francisco, San Francisco, CA, USA.
Karl KochanowskiDepartment of Pharmaceutical Chemistry, UC San Francisco, San Francisco, CA, USA.
Merisa PiperDepartment of Plastic Surgery, UC San Francisco, San Francisco, CA, USA.
Yumin XiaDepartment of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jeffrey B ChengDepartment of Dermatology, San Francisco Co-Director Epithelial Section Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, 1700 Owens Street, San Francisco, CA, 94158, USA.
Raymond J ChoDepartment of Dermatology, San Francisco Co-Director Epithelial Section Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, 1700 Owens Street, San Francisco, CA, 94158, USA.
Ruby GhadiallyDepartment of Dermatology, San Francisco Co-Director Epithelial Section Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, 1700 Owens Street, San Francisco, CA, 94158, USA. ruby.ghadially@ucsf.edu.
Broad Center · USUniversity of California, San Francisco · USSan Francisco VA Medical Center · USSecond Affiliated Hospital of Xi'an Jiaotong University · CNZagazig University · EG

Funding

RESEARCH TRAINING IN GERIATRIC MEDICINET32AG000212 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alexander Keliimoeanu Smith · 1991 to 2026
$7.7M
The role of IL17A and keratinocyte stem cells in human psoriasis.I01CX001816 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI GHADIALLY, RUBY · 2021 to 2024
–
CSRD VA I01 CX001816NIA NIH HHS T32 AG000212
6 · The paper itself

Abstract

backgroundA traditional view is that stem cells (SCs) divide slowly. Meanwhile, both embryonic and pluripotent SCs display a shorter cell cycle duration (CCD) in comparison to more committed progenitors (CPs).

methodsWe examined the in vitro proliferation and cycling behavior of somatic adult human cells using live cell imaging of passage zero keratinocytes and single-cell RNA sequencing.

resultsWe found two populations of keratinocytes: those with short CCD and protracted near exponential growth, and those with long CCD and terminal differentiation. Applying the ergodic principle, the comparative numbers of cycling cells in S phase in an enriched population of SCs confirmed a shorter CCD than CPs. Further, analysis of single-cell RNA sequencing of cycling adult human keratinocyte SCs and CPs indicated a shortening of both G1 and G2M phases in the SC.

conclusionsContrary to the pervasive paradigm, SCs progress through cell cycle more quickly than more differentiated dividing CPs. Thus, somatic human adult keratinocyte SCs may divide infrequently, but divide rapidly when they divide. Additionally, it was found that SC-like proliferation persisted in vitro.

Indexed as

Pluripotent Stem CellsAdultCell CycleCell DifferentiationCell DivisionCell ProliferationHumansKeratinocytesPhenotypeCell cycle durationCell cycle progressionCell trackingDifferentiationKeratinocyteLive cell imagingProgenitorSingle-cell RNA sequencingStem cellTime-lapse microscopy

Identifiers

PMID38475896
PMCPMC10935907
OpenAlexW4392755941

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.