SynthesisEuropean journal of medical research2024
Treatment modalities for granulomatous mastitis, seeking the most appropriate treatment with the least recurrence rate: a systematic review and meta-analysis.
Synthesis in European journal of medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Therapeutic strategies for idiopathic granulomatous mastitis: an umbrella review of systematic reviews and meta-analyses.Frontiers in medicine · 2026Pooled it
- >Efficacy of disease-modifying antirheumatic drugs in the treatment of granulomatous mastitis: a systematic review.Rheumatology international · 2024Pooled it
- Idiopathic granulomatous mastitis in the United Arab Emirates: a retrospective case series of clinical features, management, and outcomes.Clinical rheumatology · 2026Article
- Utility of intercostal artery perforator flap in granulomatous lobular mastitis: a single-center retrospective study.Gland surgery · 2026Article
- Microwave Ablation for Granulomatous Lobular Mastitis: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- An endocrine microbe immunity framework for granulomatous mastitis toward phenotype-oriented interpretation.iScience · 2026Review
- Trimethoprim-Sulfamethoxazole in the Treatment of Idiopathic Granulomatous Mastitis: A Retrospective Cohort Study.Health science reports · 2026Article
- Article
- Idiopathic Granulomatous Mastitis in a Nulliparous Woman With Autism Spectrum Disorder Receiving Long-Term Psychotropic Treatment and Normal Serum Prolactin Level: A Case Report.Clinical case reports · 2026Article
- Oxidative Stress-Related DNA Damage in Patients with Idiopathic Granulomatous Mastitis: A Prospective Case-Control Study.Journal of clinical medicine · 2026Article
- Idiopathic granulomatous mastitis: A narrative review based on the Turkish consensus classification.Turkish journal of surgery · 2026Article
- Granulomatous mastitis: from localized inflammation to systemic immune-mediated disorder.Frontiers in medicine · 2026Review
- The paradoxical effect of oral prednisone in granulomatous lobular mastitis: An observational cohort study.PloS one · 2026Observational
- Tuoli Tounong decoction promotes lesion resolution in granulomatous lobular mastitis by remodeling a Caspase-8-associated PANoptosis-like cell death network.Frontiers in immunology · 2026Article
- Acupoint glucocorticoid injection combined with focused ultrasound for granulomatous lobular mastitis: a retrospective study.Frontiers in surgery · 2026Article
- Local Triamcinolone Injection versus Anti-Tuberculosis Triple Therapy for Non-Puerperal Mastitis: A Comparative Study.International journal of women's health · 2026Article
- Article
- Methotrexate plus low-dose prednisolone compared with high-dose corticosteroid therapy in the management of idiopathic granulomatous mastitis.Archives of gynecology and obstetrics · 2025Article
- Predictors of Step-Up Therapy and Outcomes in Idiopathic Granulomatous Mastitis: A Retrospective Cohort Study in Singapore.Journal of clinical medicine · 2025Article
- Beneath the Surface: Unveiling Idiopathic Granulomatous Mastitis Within a Masquerading Breast Lump.Cureus · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGranulomatous mastitis (GM) is a rare, benign, inflammatory breast disease with an unknown etiology that predominantly affects women of reproductive age. The definitive treatment of GM is currently controversial; an appropriate therapeutic strategy has yet to be identified, and the disease's high recurrence rate remains. This study aims to determine the recurrence rate for each GM treatment strategy to identify the most appropriate treatment modality.
methodsThe search for relevant articles was undertaken using three international databases, including Medline, Scopus, and Web of Science. Articles published in English until the end of 2021 evaluating the recurrence rate of GM were included. Using Stata 13.0, the pooled incidence and 95% confidence interval (CI) for the recurrence rate were determined.
resultsSixty-five eligible studies were included in our study. The recurrence rates of systemic steroid use, topical steroid use, antibiotic use, methotrexate use, observation, drainage, excision, antibiotic use and surgery, steroid use and surgery, antibiotic and steroid use, methotrexate and steroid use were 24% (95% CI: 21-27%), 11% (95% CI: 6-21%), 18% (95% CI: 14-22%), 13% (95% CI: 7-22%), 11% (95% CI: 7-17%), 65% (95% CI: 50-78%), 13% (95% CI: 10-16%), 23% (95% CI: 14-36%), 7% (95% CI: 5-11%), 11% (95% CI: 6-18%), and 4% (95% CI: 2-8%), respectively. Drainage had the highest recurrence rate, while combined methotrexate and steroid treatment had the lowest rate.
conclusionThe optimal treatment strategy for GM depends on the disease's severity, consequences, and the patient's features. The study results indicate that combination therapy is preferable for minimizing the risk of relapse and reducing treatment complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.