Evidence map›Paper›PMID 38475816›Full record

ArticleBreast cancer research : BCR2024

Breast composition during and after puberty: the Chilean Growth and Obesity Cohort Study.

Ana Pereira, María Luisa Garmendia, Valeria Leiva, Camila Corvalán, Karin B Michels, John Shepherd

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research : BCR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 4 countries.

Ana PereiraInstitute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
María Luisa GarmendiaInstitute of Nutrition and Food Technology, University of Chile, Santiago, Chile. mgarmendia@inta.uchile.cl.
Valeria LeivaInstitute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
Camila CorvalánInstitute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
Karin B MichelsDepartment of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, USA.
John ShepherdPopulation Sciences in the Pacific Program (Cancer Epidemiology), University of Hawaii Cancer Center, Honolulu, HI, USA.
University of Chile · CLMRC Biostatistics Unit · GBUniversity of California, Los Angeles · USUniversity of Hawaii Cancer Center

Funding

Environmental chemicals and postpubertal breast composition in a Latino cohortU01ES026130 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRODY, JULIA GREEN, CORVALAN, CAMILA · 2015 to 2019
$4.4M
Predictors of Mammary Gland Development & Breast Fibroglandular Volume at pubertyR01CA158313 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MICHELS, KARIN B · 2012 to 2015
$1.9M
NCI NIH HHS R01 CA158313NIEHS NIH HHS U01 ES026130
6 · The paper itself

Abstract

backgroundBreast density (BD) is a strong risk factor for breast cancer. Little is known about how BD develops during puberty. Understanding BD trajectories during puberty and its determinants could be crucial for promoting preventive actions against breast cancer (BC) at early ages. The objective of this research is to characterize % fibroglandular volume (%FGV), absolute fibroglandular volume (AFGV), and breast volume (BV) at different breast Tanner stages until 4-year post menarche in a Latino cohort and to assess determinants of high %FGV and AFGV during puberty and in a fully mature breast.

methodsThis is a longitudinal follow-up of 509 girls from low-middle socioeconomic status of the Southeast area of Santiago, recruited at a mean age of 3.5 years. The inclusion criteria were singleton birth born, birthweight between 2500 and 4500 g with no medical or mental disorder. A trained dietitian measured weight and height since 3.5 years old and sexual maturation from 8 years old (breast Tanner stages and age at menarche onset). Using standardized methods, BD was measured using dual-energy X-ray absorptiometry (DXA) in various developmental periods (breast Tanner stage B1 until 4 years after menarche onset).

resultsIn the 509 girls, we collected 1,442 breast DXA scans; the mean age at Tanner B4 was 11.3 years. %FGV increased across breast Tanner stages and peaked 250 days after menarche. AFGV and BV peaked 2 years after menarche onset. Girls in the highest quartiles of %FGV, AFGV, and BV at Tanner B4 and B5 before menarche onset had the highest values thereafter until 4 years after menarche onset. The most important determinants of %FGV and AFGV variability were BMI z-score (R

conclusionWe characterize the breast development during puberty, a critical window of susceptibility. Although the onset of menarche is a key milestone for breast development, we observed that girls in the highest quartiles of %FGV and AFGV tracked in that group afterwards. Following these participants in adulthood would be of interest to understand the changes in breast composition during this period and its potential link with BC risk.

Indexed as

Breast NeoplasmsChildChild, PreschoolChileCohort StudiesFemaleHumansMenarcheObesityPubertyBreast compositionCohort studyLatino girlsPuberty

Identifiers

PMID38475816
PMCPMC10935788
OpenAlexW4392717603

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.