Evidence map›Paper›PMID 38474749›Full record

ReviewNutrients2024

Metabolic Effects of Selected Conventional and Alternative Sweeteners: A Narrative Review.

Fabienne Teysseire, Valentine Bordier, Christoph Beglinger, Bettina K Wölnerhanssen, Anne Christin Meyer-Gerspach

Abstract readReview
In one paragraph

Review in Nutrients, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fabienne TeysseireSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.ORCID 0000-0001-8602-9960
Valentine BordierSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.ORCID 0000-0002-1229-825X
Christoph BeglingerFaculty of Medicine, University of Basel, 4001 Basel, Switzerland.
Bettina K WölnerhanssenSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.ORCID 0000-0003-3134-2743
Anne Christin Meyer-GerspachSt. Clara Research Ltd. at St. Claraspital, 4002 Basel, Switzerland.ORCID 0000-0003-4104-8812

Funding

Swiss National Science Foundation CRSII5_186346
6 · The paper itself

Abstract

Sugar consumption is known to be associated with a whole range of adverse health effects, including overweight status and type II diabetes mellitus. In 2015, the World Health Organization issued a guideline recommending the reduction of sugar intake. In this context, alternative sweeteners have gained interest as sugar substitutes to achieve this goal without loss of the sweet taste. This review aims to provide an overview of the scientific literature and establish a reference tool for selected conventional sweeteners (sucrose, glucose, and fructose) and alternative sweeteners (sucralose, xylitol, erythritol, and D-allulose), specifically focusing on their important metabolic effects. The results show that alternative sweeteners constitute a diverse group, and each substance exhibits one or more metabolic effects. Therefore, no sweetener can be considered to be inert. Additionally, xylitol, erythritol, and D-allulose seem promising as alternative sweeteners due to favorable metabolic outcomes. These alternative sweeteners replicate the benefits of sugars (e.g., sweetness and gastrointestinal hormone release) while circumventing the detrimental effects of these substances on human health.

Indexed as

Diabetes Mellitus, Type 2Sweetening AgentsErythritolHumansSugarsXylitolErythritolSugarsSweetening AgentsXylitolD-alluloseerythritolfructoseglucosemetabolic effectssatiation mechanismssucralosesucrosesweetenersxylitol

Identifiers

PMID38474749
PMCPMC10933973

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.