Evidence map›Paper›PMID 38474693›Full record

ArticleMolecules (Basel, Switzerland)2024

Engineering Enhanced Antimicrobial Properties in α-Conotoxin RgIA through D-Type Amino Acid Substitution and Incorporation of Lysine and Leucine Residues.

Minghe Wang, Zhouyuji Liao, Dongting Zhangsun, Yong Wu, Sulan Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Marine natural products.Natural product reports · 2026
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Minghe WangGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Zhouyuji LiaoGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Dongting ZhangsunGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.
Yong WuGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.ORCID 0000-0001-6395-4213
Sulan LuoGuangxi Key Laboratory of Special Biomedicine, School of Medicine, Guangxi University, Nanning 530004, China.ORCID 0000-0002-9358-5970

Funding

DongtingZhangsun:；Yong Wu； Sulan Luo National Natural Science Foundation of China(No. 32170534), Guangxi Science and Technology Base & Talents Fund (GUIKEAD22035948), Guangxi Science and Technology Base and Talent Special Project(2021AC19001), Major Intergovernmental Joint Research Project o
6 · The paper itself

Abstract

Antimicrobial peptides (AMPs), acknowledged as host defense peptides, constitute a category of predominant cationic peptides prevalent in diverse life forms. This study explored the antibacterial activity of α-conotoxin RgIA, and to enhance its stability and efficacy, D-amino acid substitution was employed, resulting in the synthesis of nine RgIA mutant analogs. Results revealed that several modified RgIA mutants displayed inhibitory efficacy against various pathogenic bacteria and fungi, including

Indexed as

Anti-Infective AgentsConotoxinsAmino Acid SubstitutionAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesBacteriaLeucineLysineMiceMicrobial Sensitivity TestsAnti-Bacterial AgentsAnti-Infective AgentsAntimicrobial Cationic PeptidesConotoxinsLeucineLysineD-type amino acidsenzyme stabilitysafetyα-conotoxin

Identifiers

PMID38474693
PMCPMC10935098

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.