Evidence map›Paper›PMID 38474355›Full record

ArticleCells2024

The Impact of SLC2A8 RNA Interference on Glucose Uptake and the Transcriptome of Human Trophoblast Cells.

Aleksandra Lipka, Łukasz Paukszto, Victoria C Kennedy, Amelia R Tanner, Marta Majewska, Russell V Anthony

Open access · goldAbstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
3.3field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Aleksandra LipkaDepartment of Gynecology and Obstetrics, School of Medicine, Collegium Medicum, University of Warmia and Mazury in Olsztyn, 10-045 Olsztyn, Poland.ORCID 0000-0003-0815-6635
Łukasz PauksztoDepartment of Botany and Nature Protection, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-727 Olsztyn, Poland.ORCID 0000-0002-3618-1064
Victoria C KennedyCollege of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0002-9303-3607
Amelia R TannerCollege of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523, USA.
Marta MajewskaDepartment of Human Physiology and Pathophysiology, School of Medicine, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland.ORCID 0000-0001-5856-6929
Russell V AnthonyCollege of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523, USA.ORCID 0000-0003-3929-626X
Colorado State University · USUniversity of Warmia and Mazury in Olsztyn · PL

Funding

Physiological Ramifications of Chorionic Somatomammotropin DeficiencyR01HD093701 · NICHD · UNIVERSITY OF COLORADO DENVER · PI ANTHONY, RUSSELL V, ROZANCE, PAUL JOSEPH · 2018 to 2022
$2.9M
Development of Placental Glucose Transport Deficiency in an Animal ModelR21HD094952 · NICHD · COLORADO STATE UNIVERSITY · PI ANTHONY, RUSSELL V · 2019 to 2020
$407k
NICHD NIH HHS R01 HD093701NICHD NIH HHS R21 HD094952NIH HHS HD094952 and HD093701
6 · The paper itself

Abstract

While glucose is the primary fuel for fetal growth, the placenta utilizes the majority of glucose taken up from the maternal circulation. Of the facilitative glucose transporters in the placenta, SLC2A8 (GLUT8) is thought to primarily function as an intracellular glucose transporter; however, its function in trophoblast cells has not been determined. To gain insight into the function of SLC2A8 in the placenta, lentiviral-mediated RNA interference (RNAi) was performed in the human first-trimester trophoblast cell line ACH-3P. Non-targeting sequence controls (NTS RNAi;

Indexed as

PlacentaTranscriptomeFemaleGlucoseHumansPregnancyRNA InterferenceRNA, MessengerTrophoblastsGlucoseRNA, MessengerACH-3Pglucose uptakeGLUT8placentapregnancyRNA interferenceRNAseqSLC2A8trophoblast

Identifiers

PMID38474355
PMCPMC10930455
OpenAlexW4392168764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.