Evidence map›Paper›PMID 38474333›Full record

ArticleCells2024

Pre-Infection Innate Immunity Attenuates SARS-CoV-2 Infection and Viral Load in iPSC-Derived Alveolar Epithelial Type 2 Cells.

Satish Kumar, Jose Granados, Miriam Aceves, Juan Peralta, Ana C Leandro, John Thomas, Sarah Williams-Blangero, Joanne E Curran, John Blangero

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Satish KumarDivision of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, McAllen, TX 78504, USA.ORCID 0000-0002-1969-4431
Jose GranadosDivision of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, McAllen, TX 78504, USA.
Miriam AcevesDivision of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, McAllen, TX 78504, USA.ORCID 0000-0002-1778-0213
Juan PeraltaDivision of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.ORCID 0000-0002-8811-5579
Ana C LeandroDivision of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.ORCID 0000-0002-7640-3469
John ThomasDivision of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, McAllen, TX 78504, USA.ORCID 0000-0003-3816-584X
Sarah Williams-BlangeroDivision of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.
Joanne E CurranDivision of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.
John BlangeroDivision of Human Genetics and South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX 78520, USA.ORCID 0000-0001-6250-5723

Funding

Neuroimaging CoreU19AG076581 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GABRIEL Alejandro DE ERAUSQUIN, Gabriela Gonzalez_Aleman · 2023 to 2026
$32.9M
PEDIGREE ANALYSIS OF LIPOPROTEIN PHENOTYPESP01HL045522 · NHLBI · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI MAHANEY, MICHAEL CHARLES · 1991 to 2012
$27.6M
Workforce Development CoreU54HG013247 · NHGRI · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI SARAH A. WILLIAMS-BLANGERO · 2023 to 2026
$10.5M
Experimental Cellular Approaches to Genotype × Environment InteractionRM1GM149403 · NIGMS · UNIVERSITY OF TEXAS RIO GRANDE VALLEY · PI John Blangero, JOANNE E. CURRAN · 2023 to 2026
$6.6M
Construction of a Biomedical Research Facility at the U*C06RR020547 · NCRR · UNIV/TEXAS BROWNSVILLE & SOUTHMOST COLL · PI KROUSE, JOHN H · 2010 to 2010
$4.0M
NCRR NIH HHS C06 RR020547NHGRI NIH HHS U54 HG013247NHLBI NIH HHS P01 HL045522NIA NIH HHS U19 AG076581NIGMS NIH HHS RM1 GM149403NIH HHS P01 HL045522 & C06 RR020547NIH HHS U54 HG013247, U19 AG076581 and RM1 GM149403
6 · The paper itself

Abstract

A large portion of the heterogeneity in coronavirus disease 2019 (COVID-19) susceptibility and severity of illness (SOI) remains poorly understood. Recent evidence suggests that SARS-CoV-2 infection-associated damage to alveolar epithelial type 2 cells (AT2s) in the distal lung may directly contribute to disease severity and poor prognosis in COVID-19 patients. Our in vitro modeling of SARS-CoV-2 infection in induced pluripotent stem cell (iPSC)-derived AT2s from 10 different individuals showed interindividual variability in infection susceptibility and the postinfection cellular viral load. To understand the underlying mechanism of the AT2's capacity to regulate SARS-CoV-2 infection and cellular viral load, a genome-wide differential gene expression analysis between the mock and SARS-CoV-2 infection-challenged AT2s was performed. The 1393 genes, which were significantly (one-way ANOVA FDR-corrected

Indexed as

COVID-19Induced Pluripotent Stem CellsCholesterolHumansImmunity, InnateSARS-CoV-2Viral LoadCholesterolAT2sCOVID-19innate immunityin vitro modelingiPSCs

Identifiers

PMID38474333
PMCPMC10931100

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.