Evidence map›Paper›PMID 38474314›Full record

ArticleInternational journal of molecular sciences2024

Toxicity of Water-Soluble D-g-PNIPAM Polymers in a Complex with Chemotherapy Drugs and Mechanism of Their Action In Vitro.

Svitlana Prylutska, Anna Grebinyk, Stanislav Ponomarenko, Defne Gövem, Vasyl Chumachenko, Nataliya Kutsevol, Mykola Petrovsky, Uwe Ritter, Marcus Frohme, Jacek Piosik and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Svitlana PrylutskaDepartment of Plants Physiology, Biochemistry and Bioenergetics, National University of Life and Environmental Sciences of Ukraine, 03041 Kyiv, Ukraine.
Anna GrebinykDeutsches Elektronen-Synchrotron DESY, Platanenallee 6, 15738 Zeuthen, Germany.ORCID 0000-0002-4651-7908
Stanislav PonomarenkoDepartment of Biophysics and Neurobiology, Department of Chemistry, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.
Defne GövemDivision Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, 15745 Wildau, Germany.
Vasyl ChumachenkoDepartment of Biophysics and Neurobiology, Department of Chemistry, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.
Nataliya KutsevolDepartment of Biophysics and Neurobiology, Department of Chemistry, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.ORCID 0000-0002-1468-4111
Mykola PetrovskyDepartment of Biophysics and Neurobiology, Department of Chemistry, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.
Uwe RitterInstitute of Chemistry and Biotechnology, Technical University of Ilmenau, 98693 Ilmenau, Germany.ORCID 0000-0002-9315-4863
Marcus FrohmeDivision Molecular Biotechnology and Functional Genomics, Technical University of Applied Sciences Wildau, 15745 Wildau, Germany.ORCID 0000-0001-9063-2682
Jacek PiosikIntercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk, 80-307 Gdańsk, Poland.ORCID 0000-0002-5671-1915
Yuriy PrylutskyyDepartment of Biophysics and Neurobiology, Department of Chemistry, Taras Shevchenko National University of Kyiv, 01601 Kyiv, Ukraine.
Taras Shevchenko National University of Kyiv · UATechnical University of Applied Sciences Wildau · DEDeutsches Elektronen-Synchrotron DESY · DEGdańsk Medical University · PLNational University of Life and Environmental Sciences of Ukraine · UATechnische Universität Ilmenau · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The application of a biocompatible polymer nanocarrier can provide target delivery to tumor tissues, improved pharmacokinetics, controlled drug release, etc. Therefore, the proposed strategy was to use the water-soluble star-like copolymers with a Dextran core and Poly(N-isopropylacrylamide) grafts (D-g-PNIPAM) for conjugation with the widely used chemotherapy drugs in oncology-Cisplatin (Cis-Pt) and Doxorubicin (Dox). The molecular characteristics of the copolymer were received using size-exclusion chromatography. The physicochemical characterization of the D-g-PNIPAM-Cis-Pt (or Dox) nanosystem was conducted using dynamic light scattering and FTIR spectroscopy. Using traditional biochemical methods, a comparative analysis of the enhancement of the cytotoxic effect of free Cis-Pt and Dox in combination with D-g-PNIPAM copolymers was performed in cancer cells of the Lewis lung carcinoma line, which are both sensitive and resistant to Dox; in addition, the mechanism of their action in vitro was evaluated.

Indexed as

Acrylic ResinsAntineoplastic AgentsPolymersDoxorubicinDrug CarriersMicellesWaterAcrylic ResinsAntineoplastic AgentsDoxorubicinDrug CarriersMicellesPolymerspoly-N-isopropylacrylamideWatercytotoxicitydrugLewis lung carcinomastar-like copolymer

Identifiers

PMID38474314
PMCPMC10932191
OpenAlexW4392518245

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.