Evidence map›Paper›PMID 38474267›Full record

ArticleInternational journal of molecular sciences2024

Role of Advanced Glycation End Products as New Biomarkers in Systemic Lupus Erythematosus.

Irene Carrión-Barberà, Laura Triginer, Laura Tío, Carolina Pérez-García, Anna Ribes, Victoria Abad, Ana Pros, Marcelino Bermúdez-López, Eva Castro-Boqué, Albert Lecube and 4 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Biomarkers for systemic lupus erythematosus: A scoping review.Immunity, inflammation and disease · 2024
    Article
  5. Immune Mechanisms and Biomarkers in Systemic Lupus Erythematosus.International journal of molecular sciences · 2024
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Irene Carrión-BarberàRheumatology Department, Hospital del Mar, 08003 Barcelona, Spain.ORCID 0000-0002-7118-3954
Laura TriginerInflammation and Cartilage Cellular Research Group, Hospital del Mar Research Institute (IMIM), C/Dr. Aigüader 88, 08003 Barcelona, Spain.ORCID 0009-0009-2224-2987
Laura TíoInflammation and Cartilage Cellular Research Group, Hospital del Mar Research Institute (IMIM), C/Dr. Aigüader 88, 08003 Barcelona, Spain.ORCID 0000-0003-1408-7381
Carolina Pérez-GarcíaRheumatology Department, Hospital del Mar, 08003 Barcelona, Spain.
Anna RibesInflammation and Cartilage Cellular Research Group, Hospital del Mar Research Institute (IMIM), C/Dr. Aigüader 88, 08003 Barcelona, Spain.ORCID 0000-0002-3216-7230
Victoria AbadRheumatology Department, Hospital del Mar, 08003 Barcelona, Spain.
Ana ProsRheumatology Department, Hospital del Mar, 08003 Barcelona, Spain.
Marcelino Bermúdez-LópezGrupo de Investigación Translacional Vascular y Renal, IRBLleida, 25198 Lleida, Spain.ORCID 0000-0002-3188-4158
Eva Castro-BoquéGrupo de Investigación Translacional Vascular y Renal, IRBLleida, 25198 Lleida, Spain.
Albert LecubeDepartament d'Endocrinologia i Nutrició, Hospital Universitari Arnau de Vilanova, 25198 Lleida, Spain.ORCID 0000-0001-9684-0183
José Manuel ValdivielsoGrupo de Investigación Translacional Vascular y Renal, IRBLleida, 25198 Lleida, Spain.ORCID 0000-0003-1343-0184
Ilervas Project Group
Jordi MonfortRheumatology Department, Hospital del Mar, 08003 Barcelona, Spain.
Tarek Carlos Salman-MonteRheumatology Department, Hospital del Mar, 08003 Barcelona, Spain.
Hospital Del Mar · ESInstituto de Investigación Biomédica de Lleida · ESUniversitat de Lleida · ESUniversitat Autònoma de Barcelona · ES

Funding

Instituto de Salud Carlos III PI18/00059Instituto de Salud Carlos III RETIC RD16/0009/0011Ministerio de Ciencia e Innovación IJC2018-037792-ISociedad Española de Reumatología Ayuda a la Intensificación de la Actividad Investigadora (2021)Societat Catalana de Reumatologia Projectes de Recerca 2021
6 · The paper itself

Abstract

Advanced glycation end-products (AGEs) may play a relevant role as inducers in the chronic inflammatory pathway present in immune-mediated diseases, such as systemic lupus erythematosus (SLE). AGEs concentrations have been associated, with discrepant results to date, with some parameters such as disease activity or accrual damage, suggesting their potential usefulness as biomarkers of the disease. Our objectives are to confirm differences in AGEs levels measured by cutaneous autofluorescence between SLE patients and healthy controls (HC) and to study their correlation with various disease parameters. Cross-sectional study, where AGEs levels were measured by skin autofluorescence, and SLE patients' data were compared with those of sex- and age-matched HC in a 1:3 proportion through a multiple linear regression model. Associations of AGEs levels with demographic and clinical data were analyzed through ANOVA tests. Both analyses were adjusted for confounders. AGEs levels in SLE patients were significantly higher than in HC (

Indexed as

Lupus Erythematosus, SystemicBiomarkersComplement C4Cross-Sectional StudiesGlycation End Products, AdvancedHumansSeverity of Illness IndexBiomarkersComplement C4Glycation End Products, Advancedadvanced glycation end productsbiomarkerscardiovascular diseasesystemic lupus erythematosus

Identifiers

PMID38474267
PMCPMC10931748
OpenAlexW4392455062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.