Evidence map›Paper›PMID 38474244›Full record

ArticleInternational journal of molecular sciences2024

Study on the Mechanism of the Adrenaline-Evoked Procoagulant Response in Human Platelets.

Agata Gołaszewska, Tomasz Misztal, Adam Kazberuk, Tomasz Rusak

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Agata GołaszewskaDepartment of General and Experimental Pathology, Medical University of Bialystok, Mickiewicza 2C, 15-230 Bialystok, Poland.ORCID 0000-0003-1578-4162
Tomasz MisztalDepartment of Physical Chemistry, Medical University of Bialystok, Mickiewicza 2A, 15-369 Bialystok, Poland.ORCID 0000-0002-5403-9467
Adam KazberukDepartment of Medicinal Chemistry, Medical University of Bialystok, Mickiewicza 2D, 15-959 Bialystok, Poland.ORCID 0000-0002-8485-6505
Tomasz RusakDepartment of Physical Chemistry, Medical University of Bialystok, Mickiewicza 2A, 15-369 Bialystok, Poland.
Medical University of Białystok · PL

Funding

Medical University of Białystok SUB/1/DN/19/002/2201
6 · The paper itself

Abstract

Adrenaline has recently been found to trigger phosphatidylserine (PS) exposure on blood platelets, resulting in amplification of the coagulation process, but the mechanism is only fragmentarily established. Using a panel of platelet receptors' antagonists and modulators of signaling pathways, we evaluated the importance of these in adrenaline-evoked PS exposure by flow cytometry. Calcium and sodium ion influx into platelet cytosol, after adrenaline treatment, was examined by fluorimetric measurements. We found a strong reduction in PS exposure after blocking of sodium and calcium ion influx via Na

Indexed as

Blood PlateletsPlatelet ActivationCalciumEpinephrineHumansPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexSodiumThrombinCalciumEpinephrinePlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexSodiumThrombinadrenalineion exchangersmolecular mechanismoutside-in signalingphosphatidylserine exposureplateletprocoagulant response

Identifiers

PMID38474244
PMCPMC10932417
OpenAlexW4392470497

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.