Evidence map›Paper›PMID 38474199›Full record

ArticleInternational journal of molecular sciences2024

A Comparison of Spatial and Phenotypic Immune Profiles of Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions.

Thomas Enzler, Jiaqi Shi, Jake McGue, Brian D Griffith, Lei Sun, Vaibhav Sahai, Hari Nathan, Timothy L Frankel

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Pancreatic cancer.Nature reviews. Disease primers · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Thomas EnzlerDepartment of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-8775-1493
Jiaqi ShiDepartment of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-4893-1587
Jake McGueDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Brian D GriffithDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Lei SunDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Vaibhav SahaiDepartment of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0003-1892-1548
Hari NathanDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Timothy L FrankelDepartment of Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
University of Michigan · US

Funding

University of Michigan Surgical Oncology Research Training ProgramT32CA009672 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACQUELINE SARA JERUSS, WEIPING ZOU · 1991 to 2026
$6.0M
Fibroblast orchestration of the immune response in pancreatic cancerU01CA274154 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Howard C. Crawford, Timothy Louis Frankel · 2022 to 2026
$4.2M
Defining epigenetic signaling to reshape pancreatic tumor microenvironmentR37CA262209 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jiaqi Shi · 2022 to 2026
$2.3M
Epithelial-immune cell crosstalk during injury and recovery in acute pancreatitisR01DK128102 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Timothy Louis Frankel · 2022 to 2026
$2.2M
Role of environmental toxins in shaping the tumor immune microenvironmentI01BX005777 · VA · VETERANS HEALTH ADMINISTRATION · PI FRANKEL, TIMOTHY LOUIS · 2022 to 2025
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BLRD VA I01 BX005777NCI NIH HHS R37 CA262209NCI NIH HHS R37CA262209NCI NIH HHS T32 CA009672NCI NIH HHS U01 CA274154NCI NIH HHS U01CA274154NIDDK NIH HHS R01 DK128102NIH HHS 5R01DK128102
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of 12.5%. PDAC predominantly arises from non-cystic pancreatic intraepithelial neoplasia (PanIN) and cystic intraductal papillary mucinous neoplasm (IPMN). We used multiplex immunofluorescence and computational imaging technology to characterize, map, and compare the immune microenvironments (IMEs) of PDAC and its precursor lesions. We demonstrate that the IME of IPMN was abundantly infiltrated with CD8

Indexed as

Carcinoma in SituCarcinoma, Pancreatic DuctalPancreatic Intraductal NeoplasmsPancreatic NeoplasmsB7-H1 AntigenCD8-Positive T-LymphocytesHumansProgrammed Cell Death 1 ReceptorTumor MicroenvironmentB7-H1 AntigenProgrammed Cell Death 1 Receptorimmune microenvironmentimmunotherapypancreatic cancer precursor lesionspancreatic ductal adenocarcinoma

Identifiers

PMID38474199
PMCPMC10932200
OpenAlexW4392376376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.