Evidence map›Paper›PMID 38474188›Full record

ArticleInternational journal of molecular sciences2024

Defective Biomechanics and Pharmacological Rescue of Human Cardiomyocytes with Filamin C Truncations.

Marco Lazzarino, Michele Zanetti, Suet Nee Chen, Shanshan Gao, Brisa Peña, Chi Keung Lam, Joseph C Wu, Matthew R G Taylor, Luisa Mestroni, Orfeo Sbaizero

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Cardiac disease mechanobiology: advances using hiPSC-CMs.Frontiers in cardiovascular medicine · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Marco LazzarinoCNR-IOM, Area Science Park, 34149 Trieste, Italy.ORCID 0000-0003-1077-6569
Michele ZanettiCNR-IOM, Area Science Park, 34149 Trieste, Italy.ORCID 0000-0002-5581-1754
Suet Nee ChenCardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-9519-9416
Shanshan GaoCardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-4194-3630
Brisa PeñaCardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-4224-6626
Chi Keung LamStanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-4565-9426
Joseph C WuStanford Cardiovascular Institute, Stanford University, Stanford, CA 94305, USA.
Matthew R G TaylorCardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-9043-0810
Luisa MestroniCardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-1116-2286
Orfeo SbaizeroCardiovascular Institute, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-8933-5071
University of Colorado Anschutz Medical Campus · USAREA Science Park · ITCardiovascular Institute of the South · USUniversity of Trieste · IT

Funding

POSTGRADUATE TRAINING IN CARDIOVASCULAR RESEARCHT32HL007822 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI BUTTRICK, PETER N., LEINWAND, LESLIE ANNE · 1996 to 2023
$6.2M
Engineering Cardiac spheroids to study LaminopathiesR01HL164634 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Luisa Mestroni, Matthew R Taylor · 2023 to 2026
$2.8M
Cardiomyocyte phenotype and mechanotransduction in Filamin C gene variants causing arrhythmogenic cardiomyopathyR01HL147064 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MESTRONI, LUISA, TAYLOR, MATTHEW R · 2020 to 2023
$2.1M
Injectable Carbon Nanotube-Functionalized Hydrogel for miRNA DeliveryK25HL148386 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI PENA CASTELLANOS, BRISA MARISOL · 2020 to 2024
$891k
NHLBI NIH HHS K25 HL148386NHLBI NIH HHS R01 HL147064NHLBI NIH HHS R01 HL164634NHLBI NIH HHS T32 HL007822NIH HHS 5T32HL007822-23NIH HHS K25HL148386NIH HHS R01HL147064NIH HHS R01HL164634
6 · The paper itself

Abstract

Actin-binding filamin C (FLNC) is expressed in cardiomyocytes, where it localizes to Z-discs, sarcolemma, and intercalated discs. Although FLNC truncation variants (

Indexed as

Induced Pluripotent Stem CellsMyocytes, CardiacActinsBiomechanical PhenomenaFilaminsHumansMyocardiumActinsFilaminsarrhythmogenic cardiomyopathyatomic force microscopycardiomyocytesfilamin Cgeneticsinduced pluripotent stem cellsmechanomics

Identifiers

PMID38474188
PMCPMC10932268
OpenAlexW4392376442

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.