Evidence map›Paper›PMID 38474182›Full record

ArticleInternational journal of molecular sciences2024

Inhibitory Efficacy of Main Components of

Cheng-Han Lin, Ho-Ju Chang, Meng-Wei Lin, Xin-Rui Yang, Che-Hsiung Lee, Chih-Sheng Lin

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Cheng-Han LinDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.
Ho-Ju ChangDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.
Meng-Wei LinDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.
Xin-Rui YangDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.
Che-Hsiung LeeDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.ORCID 0000-0002-6164-4884
Chih-Sheng LinDepartment of Biological Science and Technology, National Yang Ming Chiao Tung University, Hsinchu 30068, Taiwan.ORCID 0000-0003-1140-7933
National Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blocking the interaction between the SARS-CoV-2 spike protein and the human angiotensin-converting enzyme II (hACE2) protein serves as a therapeutic strategy for treating COVID-19. Traditional Chinese medicine (TCM) treatments containing bioactive products could alleviate the symptoms of severe COVID-19. However, the emergence of SARS-CoV-2 variants has complicated the process of developing broad-spectrum drugs. As such, the aim of this study was to explore the efficacy of TCM treatments against SARS-CoV-2 variants through targeting the interaction of the viral spike protein with the hACE2 receptor. Antiviral activity was systematically evaluated using a pseudovirus system.

Indexed as

COVID-19FlavonesAngiotensinsHumansProtein BindingSARS-CoV-2Scutellaria baicalensisSpike Glycoprotein, CoronavirusAngiotensinsFlavonesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2angiotensin-converting enzyme 2 (ACE2)baicaleinbaicalinSARS-CoV-2Scutellaria baicalensisspike proteintraditional Chinese medicine

Identifiers

PMID38474182
PMCPMC10932139
OpenAlexW4392376345

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.