Evidence map›Paper›PMID 38474038›Full record

ArticleInternational journal of molecular sciences2024

Bactericidal Efficacy of the Combination of Maresin-like Proresolving Mediators and Carbenicillin Action on Biofilm-Forming Burn Trauma Infection-Related Bacteria.

Anbu Mozhi Thamizhchelvan, Abdul-Razak Masoud, Shanchun Su, Yan Lu, Hongying Peng, Yuichi Kobayashi, Yu Wang, Nathan K Archer, Song Hong

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Maresins.Biomolecules · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Anbu Mozhi ThamizhchelvanNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., New Orleans, LA 70112, USA.ORCID 0000-0002-8840-6667
Abdul-Razak MasoudNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., New Orleans, LA 70112, USA.ORCID 0000-0002-8621-4063
Shanchun SuNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., New Orleans, LA 70112, USA.
Yan LuNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., New Orleans, LA 70112, USA.
Hongying PengBiostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati, OH 45221, USA.
Yuichi KobayashiDepartment of Bioengineering, Tokyo Institute of Technology, Box B-52, Nagatsuta-cho 4259, Midori-ku, Yokohama 226-8501, Kanagawa, Japan.ORCID 0000-0002-4385-9531
Yu WangDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.
Nathan K ArcherDepartment of Dermatology, Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0002-8212-8985
Song HongNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., New Orleans, LA 70112, USA.
Louisiana State University Health Sciences Center New Orleans · USJohns Hopkins University · USTokyo Institute of Technology · JPUniversity of Cincinnati Medical Center · US

Funding

Regenerative Lipid Mediators for the Management of Severe Burn WoundsR01GM136874 · NIGMS · LSU HEALTH SCIENCES CENTER · PI HONG, SONG · 2020 to 2023
$2.1M
A Novel Resolution Strategy on Chronic Inflammation and Impaired Healing of Wounds in AgingR21AG066119 · NIA · LSU HEALTH SCIENCES CENTER · PI HONG, SONG · 2020 to 2021
$805k
Explore the Comparative Biology on Effects of Skin Ulceration on AD-Pathological NeurodegenerationR21AG068756 · NIA · LSU HEALTH SCIENCES CENTER · PI HONG, SONG · 2020 to 2022
$422k
NIA NIH HHS R21 AG066119NIA NIH HHS R21 AG068756NIGMS NIH HHS R01 GM136874
6 · The paper itself

Abstract

Biofilm-associated bacterial infections are the major reason for treatment failure in many diseases including burn trauma infections. Uncontrolled inflammation induced by bacteria leads to materiality, tissue damage, and chronic diseases. Specialized proresolving mediators (SPMs), including maresin-like lipid mediators (MarLs), are enzymatically biosynthesized from omega-3 essential long-chain polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), by macrophages and other leukocytes. SPMs exhibit strong inflammation-resolving activities, especially inflammation provoked by bacterial infection. In this study, we explored the potential direct inhibitory activities of three MarLs on Gram-positive

Indexed as

BurnsCommunicable DiseasesStaphylococcal InfectionsWound InfectionAnti-Bacterial AgentsBacteriaBiofilmsCarbenicillinEscherichia coliGram-Negative BacteriaGram-Positive BacteriaHumansInflammationMicrobial Sensitivity TestsAnti-Bacterial AgentsCarbenicillinantimicrobial lipidsantimicrobial resistancebactericidal antibacterialbiofilmsfatty acidsGram negativeGram positivemaresin-like lipid mediator (MarL)microbial infectionsspecialized proresolving mediators (SPMs)

Identifiers

PMID38474038
PMCPMC10932429
OpenAlexW4392237592

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.