Evidence map›Paper›PMID 38474029›Full record

ArticleInternational journal of molecular sciences2024

Identification of Endothelial Cell Protein C Receptor by Urinary Proteomics as Novel Prognostic Marker in Non-Recovery Kidney Injury.

Chih-Hsiang Chang, Cheng-Chia Lee, Yung-Chang Chen, Pei-Chun Fan, Pao-Hsien Chu, Lichieh Julie Chu, Jau-Song Yu, Hsiao-Wei Chen, Chih-Wei Yang, Yi-Ting Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Chih-Hsiang ChangKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan.ORCID 0000-0002-7342-335X
Cheng-Chia LeeKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan.ORCID 0000-0002-6973-5908
Yung-Chang ChenKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan.
Pei-Chun FanKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan.ORCID 0000-0003-2974-249X
Pao-Hsien ChuDepartment of Cardiology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan.ORCID 0000-0003-0361-6348
Lichieh Julie ChuMolecular Medicine Research Center, Chang Gung University, Guishan, Taoyuan 333, Taiwan.ORCID 0000-0002-8488-9614
Jau-Song YuMolecular Medicine Research Center, Chang Gung University, Guishan, Taoyuan 333, Taiwan.ORCID 0000-0002-4295-983X
Hsiao-Wei ChenMolecular Medicine Research Center, Chang Gung University, Guishan, Taoyuan 333, Taiwan.
Chih-Wei YangKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan.
Yi-Ting ChenKidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan.ORCID 0000-0002-0063-4965
Chang Gung University · TW

Funding

Chang Gung Memorial Hospital CMRPD1L0091Chang Gung Memorial Hospital CMRPG3F1653Chang Gung Memorial Hospital CMRPVVM0081National Taiwan University of Science and Technology MOST 111-2113-M-182-002
6 · The paper itself

Abstract

Acute kidney injury is a common and complex complication that has high morality and the risk for chronic kidney disease among survivors. The accuracy of current AKI biomarkers can be affected by water retention and diuretics. Therefore, we aimed to identify a urinary non-recovery marker of acute kidney injury in patients with acute decompensated heart failure. We used the isobaric tag for relative and absolute quantification technology to find a relevant marker protein that could divide patients into control, acute kidney injury with recovery, and acute kidney injury without recovery groups. An enzyme-linked immunosorbent assay of the endothelial cell protein C receptor (EPCR) was used to verify the results. We found that the EPCR was a usable marker for non-recovery renal failure in our setting with the area under the receiver operating characteristics 0.776 ± 0.065; 95%CI: 0.648-0.905, (

Indexed as

Acute Kidney InjuryBlood Coagulation FactorsHeart FailureReceptors, Cell SurfaceBiomarkersEndothelial Protein C ReceptorHumansKidneyPrognosisProteomicsactivated protein C receptorBiomarkersBlood Coagulation FactorsEndothelial Protein C ReceptorReceptors, Cell Surfaceacute decompensated heart failureacute kidney injuryendothelial cell protein C receptor (EPCR)fibrosis

Identifiers

PMID38474029
PMCPMC10931920
OpenAlexW4392237557

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.