Evidence map›Paper›PMID 38474005›Full record

ArticleInternational journal of molecular sciences2024

Intrinsic Lipid Curvature and Bilayer Elasticity as Regulators of Channel Function: A Comparative Single-Molecule Study.

Mohammad Ashrafuzzaman, Roger E Koeppe, Olaf S Andersen

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Biocontrol Potential of NativeJournal of fungi (Basel, Switzerland) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Mohammad AshrafuzzamanDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA.
Roger E KoeppeDepartment of Chemistry and Biochemistry, University of Arkansas, Fayetteville, AR 72701, USA.ORCID 0000-0003-0676-6413
Olaf S AndersenDepartment of Physiology and Biophysics, Weill Cornell Medicine, New York, NY 10065, USA.ORCID 0000-0002-3026-6710
Cornell University · USUniversity of Arkansas at Fayetteville · US

Funding

Structure based drug discoveryP20RR015569 · NCRR · UNIVERSITY OF ARKANSAS AT FAYETTEVILLE · PI MILLETT, FRANCIS S · 2000 to 2009
$21.4M
Energetics of Channel-Bilayer InteractionsR01GM021342 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ANDERSEN, OLAF S. · 1985 to 2021
$9.9M
NCRR NIH HHS P20 RR015569NIGMS NIH HHS R01 GM021342
6 · The paper itself

Abstract

Perturbations in bilayer material properties (thickness, lipid intrinsic curvature and elastic moduli) modulate the free energy difference between different membrane protein conformations, thereby leading to changes in the conformational preferences of bilayer-spanning proteins. To further explore the relative importance of curvature and elasticity in determining the changes in bilayer properties that underlie the modulation of channel function, we investigated how the micelle-forming amphiphiles Triton X-100, reduced Triton X-100 and the H

Indexed as

GramicidinLipid BilayersElasticityOctoxynolPeptaibolsGramicidinLipid BilayersOctoxynolPeptaibolsalamethicin channelamphiphilesbilayer-mediated regulationelasticitygramicidin channellipid intrinsic curvature

Identifiers

PMID38474005
PMCPMC10931550
OpenAlexW4392200241

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.