ReviewInternational journal of molecular sciences2024
Importance of Metalloproteinase 8 (MMP-8) in the Diagnosis of Periodontitis.
Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Levels of IL-1β, MMP-8, and MMP-9 in the Saliva of Subjects With Periodontitis: A Systematic Review and Meta-Analysis.Journal of clinical laboratory analysis · 2025Pooled it
- Relationship Between MCP-1 Levels in GCF and Periodontitis: A Systematic Review With Meta-Analysis and Analysis of Molecular Interactions.Journal of cellular and molecular medicine · 2025Pooled it
- Impact of a Dietary Supplementation with French Maritime Pine Bark Extract PycnogenolNutrients · 2025Trial
- Analysis of Matrix Metalloproteinase-8 Gene Polymorphisms and Their Association with Long-Term Survival, Clinical Phenotype, and Disease Risk in Patients with Coronary Artery Disease.International journal of molecular sciences · 2026Article
- Influence of Genetic and Epigenetic Factors on Periodontitis Susceptibility and Treatment Outcomes.Biochemical genetics · 2026Review
- Clinical Status and Salivary aMMP-8 Evaluation of 0.12% Chlorhexidine Versus MicroRepairDentistry journal · 2026Article
- Long Non-coding RNA TLX1NB Regulates Inflammatory Response in Periodontitis by Interacting With Matrix Metalloproteinase 8.Inflammation · 2026Article
- Prediction of depressive episodes based on clinical features, cognitive characteristics, inflammation-related proteins, and EEG data.Translational psychiatry · 2026Article
- CCR1Frontiers in immunology · 2026Article
- S100A8/A9 Inhibition Reduces Neutrophil Extracellular Trap Formation and Mitigates Sepsis-Related Liver Injury.Journal of inflammation research · 2026Article
- Innovative Biomarkers for Oral Immunity: Advancements and Clinical Applications.Advances in experimental medicine and biology · 2026Review
- Neutrophils at the Crossroads of Oral Microbiome Dysbiosis and Periodontal Disease.Microorganisms · 2025Review
- Salivary and Microbiome Biomarkers in Periodontitis: Advances in Diagnosis and Therapy-A Narrative Review.Medicina (Kaunas, Lithuania) · 2025Review
- Isthmin 1, matrix metalloproteinase 8 and asprosin as potential biomarkers in periodontitis with obesity.BMC oral health · 2025Article
- Salivary Biomarker Analysis to Distinguish Between Health and Periodontitis Status: A Preliminary Study.Dentistry journal · 2025Article
- Reply to Markaryan et al. Comment on "Aji et al. aMMP-8 POCT vs. Other Potential Biomarkers in Chair-Side Diagnostics and Treatment Monitoring of Severe Periodontitis.International journal of molecular sciences · 2025Article
- Matrix Metalloproteinase Inhibitors and Their Potential Clinical Application in Periodontitis.Diseases (Basel, Switzerland) · 2025Review
- A prospective observational study regarding host-derived immunological parameters around zirconia implants in comparison to natural teeth following flap surgery.Scientific reports · 2025Observational
- The Influence of Injectable Platelet-Rich Fibrin on the Clinical Parameters and the Levels of MMP-8 in the GCF in Non-Surgical Treatment of Periodontitis-Randomized Trial.Journal of functional biomaterials · 2025Article
- Biosensors based on organic transistors for intraoral biomarker detection.Mikrochimica acta · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis is a complex condition. Left untreated, it leads to tooth loss and the need for prosthetic treatment. The incidence of periodontitis is steadily increasing, so new methods are being sought to aid in the diagnosis of the disease. Among the methods postulated is the determination of concentrations of bioactive compounds which include extracellular matrix metalloproteinases (MMPs). These enzymes are present in various structural elements of the stomatognathic system. The most promising enzyme of this group appears to be metalloproteinase 8 (MMP-8). MMP-8 assays are performed in gingival fluid or saliva, and MMP-8 levels have been shown to be higher in patients with periodontitis compared to healthy subjects and correlated with some clinical parameters of the condition and the severity of the disease. In addition, the preliminary usefulness of this enzyme in evaluating the effectiveness of periodontal treatment and doxycycline therapy has been demonstrated. Determination of the active form of MMP-8 (aMMP-8) in oral rinse fluid using off-the-shelf assays shows the highest potential. Despite reports about aMMP-8 and promising data on the role of MMP-8 in periodontal diagnosis, a clear determination of the usefulness of this enzyme requires further research.
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Registered trials
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