Evidence map›Paper›PMID 38473947›Full record

SynthesisInternational journal of molecular sciences2024

A Systematic Review and Meta-Analysis of the Pathology Underlying Aneurysm Enhancement on Vessel Wall Imaging.

Ronneil Digpal, Kenton P Arkill, Regan Doherty, Joseph Yates, Lorna K Milne, Nicole Broomes, Orestis L Katsamenis, Jason Macdonald, Adam Ditchfield, Ana Paula Narata and 5 more

Open access · goldAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Clinical implications of vessel wall imaging-State-of-the-art review.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Ronneil DigpalDepartment of Neurosurgery, Wessex Neurological Centre, University Hospital Southampton, Southampton SO16 6YD, UK.
Kenton P ArkillBiodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0002-3360-6055
Regan DohertyBiomedical Imaging Unit, University of Southampton, Southampton SO16 6YD, UK.ORCID 0000-0002-8451-8303
Joseph YatesDepartment of Neuropathology, University Hospital Southampton, Southampton SO16 6YD, UK.ORCID 0000-0002-4236-2996
Lorna K MilneBiodiscovery Institute, University of Nottingham, Nottingham NG7 2RD, UK.ORCID 0000-0002-1078-2363
Nicole BroomesDepartment of Neurosurgery, Wessex Neurological Centre, University Hospital Southampton, Southampton SO16 6YD, UK.
Orestis L KatsamenisFaculty of Engineering and Physical Sciences, µ-VIS X-ray Imaging Centre, University of Southampton, Southampton SO16 6YD, UK.ORCID 0000-0003-4367-4147
Jason MacdonaldDepartment of Neuroradiology, Wessex Neurological Centre, University Hospital Southampton, Southampton SO16 6YD, UK.
Adam DitchfieldDepartment of Neuroradiology, Wessex Neurological Centre, University Hospital Southampton, Southampton SO16 6YD, UK.
Ana Paula NarataDepartment of Neuroradiology, Wessex Neurological Centre, University Hospital Southampton, Southampton SO16 6YD, UK.
Angela DarekarMedical Physics, University Hospital Southampton, Southampton SO16 6YD, UK.ORCID 0000-0002-5050-1351
Roxana O CarareClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.
Mark FabianDepartment of Neuropathology, University Hospital Southampton, Southampton SO16 6YD, UK.ORCID 0000-0003-2498-9995
Ian GaleaClinical Neurosciences, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, UK.ORCID 0000-0002-1268-5102
Diederik BultersDepartment of Neurosurgery, Wessex Neurological Centre, University Hospital Southampton, Southampton SO16 6YD, UK.ORCID 0000-0001-9884-9050
University Hospital Southampton NHS Foundation Trust · GBUniversity of Southampton · GBUniversity of Nottingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracranial aneurysms are common, but only a minority rupture and cause subarachnoid haemorrhage, presenting a dilemma regarding which to treat. Vessel wall imaging (VWI) is a contrast-enhanced magnetic resonance imaging (MRI) technique used to identify unstable aneurysms. The pathological basis of MR enhancement of aneurysms is the subject of debate. This review synthesises the literature to determine the pathological basis of VWI enhancement. PubMed and Embase searches were performed for studies reporting VWI of intracranial aneurysms and their correlated histological analysis. The risk of bias was assessed. Calculations of interdependence, univariate and multivariate analysis were performed. Of 228 publications identified, 7 met the eligibility criteria. Individual aneurysm data were extracted for 72 out of a total of 81 aneurysms. Univariate analysis showed macrophage markers (CD68 and MPO,

Indexed as

Aneurysm, RupturedIntracranial AneurysmSubarachnoid HemorrhageHumansImage EnhancementMagnetic Resonance Imaginganeurysm-wall enhancementhistologyintracranial aneurysmmagnetic resonance imagingpathologyvessel wall imaging

Identifiers

PMID38473947
PMCPMC10931983
OpenAlexW4392162927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.