Evidence map›Paper›PMID 38473936›Full record

ArticleInternational journal of molecular sciences2024

Oral Ingestion of Yuzu Seed Oil Suppresses the Development of Atopic Dermatitis-like Skin Lesions in NC/Nga Mice.

Kimito Asano, Yoshiya Watanabe, Mio Miyamoto, Mochifumi Toutani, Shunji Mizobuchi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kimito AsanoKochi-Umajimura Yuzu Health Research Course, Kochi Medical School, Kochi University, Nankoku 783-8505, Japan.
Yoshiya WatanabeKochi-Umajimura Yuzu Health Research Course, Kochi Medical School, Kochi University, Nankoku 783-8505, Japan.
Mio MiyamotoKochi-Umajimura Yuzu Health Research Course, Kochi Medical School, Kochi University, Nankoku 783-8505, Japan.ORCID 0000-0002-3077-8898
Mochifumi ToutaniUmajimura Agricultural Cooperative, Kochi 781-6201, Japan.
Shunji MizobuchiKochi-Umajimura Yuzu Health Research Course, Kochi Medical School, Kochi University, Nankoku 783-8505, Japan.ORCID 0000-0003-1564-0898
Kōchi University · JP

Funding

Umajimura Agricultural Cooperative 7002-72
6 · The paper itself

Abstract

Long-term oral ingestion of unheated yuzu seed oil in humans reduces lipid peroxides in the blood. Moreover, yuzu seed oil contains limonin, which can induce antioxidant and anti-inflammatory effects by activating the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). Previously, Nrf2 has been shown to reduce atopic dermatitis (AD). Therefore, we hypothesized that ingesting unheated yuzu seed oil can regulate AD through Nrf2. An AD model was established using NC/Nga mice through repeated local exposure to mite antigens. Unheated and purified yuzu seed oil (100 µL/mice) or water (control, 100 µL/mice) was administered orally once a day using a gastric cannula for rodents for 28 days. On day 28, mice in the unheated yuzu seed oil group exhibited significantly lower clinical skin severity scores and ear thickness than those in the purified yuzu seed oil and water groups. Serum histamine levels remained unaltered among the three AD-induced groups. Serum

Indexed as

Dermatitis, AtopicAnimalsDermatophagoides farinaeDisease Models, AnimalEatingHumansImmunoglobulin EMiceNF-E2-Related Factor 2Plant OilsSkinImmunoglobulin ENF-E2-Related Factor 2Plant Oilsantioxidant effectatopic dermatitislimoninNrf2yuzu seed oil

Identifiers

PMID38473936
PMCPMC10932159
OpenAlexW4392163132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.