Evidence map›Paper›PMID 38473933›Full record

ArticleInternational journal of molecular sciences2024

Studying the Effect of MBNL1 and MBNL2 Loss in Skeletal Muscle Regeneration.

Ramesh S Yadava, Mahua Mandal, Mani S Mahadevan

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Ramesh S YadavaDepartment of Pathology, University of Virginia, Charlottesville, VA 22908, USA.ORCID 0000-0002-0092-5033
Mahua MandalDepartment of Pathology, University of Virginia, Charlottesville, VA 22908, USA.
Mani S MahadevanDepartment of Pathology, University of Virginia, Charlottesville, VA 22908, USA.
University of Virginia · US

Funding

The role of TGFβs and cFAPs in Cardiac Pathology from RNA ToxicityR01HL169790 · NHLBI · UNIVERSITY OF VIRGINIA · PI Ramesh Yadava · 2023 to 2026
$3.2M
RNA Toxicity and Muscle RegenerationR01AR071170 · NIAMS · UNIVERSITY OF VIRGINIA · PI MAHADEVAN, MANI SUBRAMANIAM · 2017 to 2021
$2.0M
RNA Toxicity and Cardiac PathologyR56HL162953 · NHLBI · UNIVERSITY OF VIRGINIA · PI MAHADEVAN, MANI SUBRAMANIAM · 2022 to 2022
$755k
NHLBI NIH HHS R01 HL169790NHLBI NIH HHS R56 HL162953NIAMS NIH HHS R01 AR071170NIH HHS 1R01AR071170NIH HHS 1R56HL162953
6 · The paper itself

Abstract

Loss of function of members of the muscleblind-like (MBNL) family of RNA binding proteins has been shown to play a key role in the spliceopathy of RNA toxicity in myotonic dystrophy type 1 (DM1), the most common muscular dystrophy affecting adults and children. MBNL1 and MBNL2 are the most abundantly expressed members in skeletal muscle. A key aspect of DM1 is poor muscle regeneration and repair, leading to dystrophy. We used a BaCl

Indexed as

Alternative SplicingMyotonic DystrophyAnimalsChildDisease Models, AnimalHumansMiceMice, KnockoutMuscle, SkeletalRNARNA-Binding ProteinsMBNL1 protein, humanMBNL2 protein, humanRNARNA-Binding Proteinsmuscleblindmuscle regenerationmuscular dystrophymyotonic dystrophyRNA binding proteinsRNA toxicitysatellite cells

Identifiers

PMID38473933
PMCPMC10931579
OpenAlexW4392166314

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.