Evidence map›Paper›PMID 38473887›Full record

ReviewInternational journal of molecular sciences2024

miRNA Regulation of Cell Phenotype and Parietal Remodeling in Atherosclerotic and Non-Atherosclerotic Aortic Aneurysms: Differences and Similarities.

Sonia Terriaca, Amedeo Ferlosio, Maria Giovanna Scioli, Francesca Coppa, Fabio Bertoldo, Calogera Pisano, Beatrice Belmonte, Carmela Rita Balistreri, Augusto Orlandi

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Sonia TerriacaAnatomic Pathology, Policlinico Tor Vergata, 00133 Rome, Italy.
Amedeo FerlosioAnatomic Pathology, Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy.
Maria Giovanna ScioliAnatomic Pathology, Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy.ORCID 0000-0002-8458-4108
Francesca CoppaAnatomic Pathology, Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy.
Fabio BertoldoCardiac Surgery Unit, Department of Surgery, Tor Vergata University, 00133 Rome, Italy.
Calogera PisanoCardiac Surgery Unit, Department of Surgery, Tor Vergata University, 00133 Rome, Italy.ORCID 0000-0002-6488-1965
Beatrice BelmonteTumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.ORCID 0000-0001-9668-0925
Carmela Rita BalistreriCellular and Molecular Laboratory, Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), University of Palermo, 90134 Palermo, Italy.ORCID 0000-0002-5393-1007
Augusto OrlandiAnatomic Pathology, Department of Biomedicine and Prevention, Tor Vergata University, 00133 Rome, Italy.ORCID 0000-0001-7202-5854
University of Rome Tor Vergata · ITIstituto Nazionale di Fisica Nucleare, Sezione di Catania · ITPoliclinico Tor Vergata · ITUniversity of Palermo · IT

Funding

European Union-Next Generation UE PNRR-MR1-2022-12376699
6 · The paper itself

Abstract

Aortic aneurysms are a serious health concern as their rupture leads to high morbidity and mortality. Abdominal aortic aneurysms (AAAs) and thoracic aortic aneurysms (TAAs) exhibit differences and similarities in their pathophysiological and pathogenetic features. AAA is a multifactorial disease, mainly associated with atherosclerosis, characterized by a relevant inflammatory response and calcification. TAA is rarely associated with atherosclerosis and in some cases is associated with genetic mutations such as Marfan syndrome (MFS) and bicuspid aortic valve (BAV). MFS-related and non-genetic or sporadic TAA share aortic degeneration with endothelial-to-mesenchymal transition (End-Mt) and fibrosis, whereas in BAV TAA, aortic degeneration with calcification prevails. microRNA (miRNAs) contribute to the regulation of aneurysmatic aortic remodeling. miRNAs are a class of non-coding RNAs, which post-transcriptionally regulate gene expression. In this review, we report the involvement of deregulated miRNAs in the different aortic remodeling characterizing AAAs and TAAs. In AAA, miRNA deregulation appears to be involved in parietal inflammatory response, smooth muscle cell (SMC) apoptosis and aortic wall calcification. In sporadic and MFS-related TAA, miRNA deregulation promotes End-Mt, SMC myofibroblastic phenotypic switching and fibrosis with glycosaminoglycan accumulation. In BAV TAA, miRNA deregulation sustains aortic calcification. Those differences may support the development of more personalized therapeutic approaches.

Indexed as

Aortic AneurysmAortic Aneurysm, ThoracicAtherosclerosisBicuspid Aortic Valve DiseaseCalcinosisMarfan SyndromeMicroRNAsAortic ValveFibrosisHumansPhenotypeMicroRNAsabdominal aortic aneurysmatherosclerosisbicuspid aortic valvecalcificationendothelial dysfunctionfibrosisMarfan syndromemiRNA deregulationsmooth muscle cell dedifferentiationthoracic aortic aneurysm

Identifiers

PMID38473887
PMCPMC10932122
OpenAlexW4392163329

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.