Evidence map›Paper›PMID 38473806›Full record

ArticleInternational journal of molecular sciences2024

Cisplatin Nephrotoxicity Is Critically Mediated by the Availability of BECLIN1.

Tillmann Bork, Camila Hernando-Erhard, Wei Liang, Zhejia Tian, Kosuke Yamahara, Tobias B Huber

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Tillmann BorkDepartment of Medicine IV, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Camila Hernando-ErhardDepartment of Medicine IV, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Wei LiangDepartment of Medicine IV, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.ORCID 0000-0002-1098-5662
Zhejia TianDepartment of Nephrology and Hypertension, Hannover Medical School, 30625 Hannover, Germany.
Kosuke YamaharaDepartment of Medicine IV, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Tobias B HuberIII Department of Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
University of Freiburg · DEMedizinische Hochschule Hannover · DEShiga University of Medical Science · JPUniversität Hamburg · DE

Funding

European Research Council 616891
6 · The paper itself

Abstract

Cisplatin nephrotoxicity is a critical limitation of solid cancer treatment. Until now, the complex interplay of various pathophysiological mechanisms leading to proximal tubular cell apoptosis after cisplatin exposure has not been fully understood. In our study, we assessed the role of the autophagy-related protein BECLIN1 (ATG6) in cisplatin-induced acute renal injury (AKI)-a candidate protein involved in autophagy and with putative impact on apoptosis by harboring a B-cell lymphoma 2 (BCL2) interaction site of unknown significance. By using mice with heterozygous deletion of

Indexed as

Acute Kidney InjuryCisplatinAnimalsApoptosisAutophagyBeclin-1MiceBeclin-1CisplatinAKIapoptosisautophagyBECLIN1cisplatinER stress

Identifiers

PMID38473806
PMCPMC10931997
OpenAlexW4392045336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.