Evidence map›Paper›PMID 38473790›Full record

ArticleInternational journal of molecular sciences2024

Evidence of the Role of Inflammation and the Hormonal Environment in the Pathogenesis of Adrenal Myelolipomas in Congenital Adrenal Hyperplasia.

Vipula Kolli, Emily Frucci, Isabela Werneck da Cunha, James R Iben, Sun A Kim, Ashwini Mallappa, Tianwei Li, Fabio Rueda Faucz, Electron Kebebew, Naris Nilubol and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Vipula KolliNational Institutes of Health Clinical Center, 10 Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0002-1175-8269
Emily FrucciNational Institutes of Health Clinical Center, 10 Center Drive, Bethesda, MD 20892, USA.
Isabela Werneck da CunhaLaboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA.
James R IbenThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
Sun A KimLaboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA.
Ashwini MallappaNational Institutes of Health Clinical Center, 10 Center Drive, Bethesda, MD 20892, USA.
Tianwei LiThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
Fabio Rueda FauczThe Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.ORCID 0000-0001-7959-9842
Electron KebebewDivision of General Surgery, Department of Surgery, Stanford University School of Medicine, Palo Alto, CA 94304, USA.
Naris NilubolNational Cancer Institute, Bethesda, MD 20892, USA.
Martha M QuezadoLaboratory of Pathology, National Cancer Institute, Bethesda, MD 20892, USA.
Deborah P MerkeNational Institutes of Health Clinical Center, 10 Center Drive, Bethesda, MD 20892, USA.ORCID 0000-0002-3746-0460
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Cancer Institute · USNational Institutes of Health Clinical Center · USD’Or Institute for Research and Education · BRStanford University · US

Funding

Surgical Oncology Program Training ProgramZIEBC012097 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI BLAKELY, ANDREW · 2022 to 2025
$17.3M
Natural History Study of Patients with Excess AndrogenZIACL090091 · CLC · CLINICAL CENTER · PI MERKE, DEBORAH · 2022 to 2025
$0k
6 · The paper itself

Abstract

Adrenal myelolipomas (AML) are composed of mature adipose and hematopoietic components. They represent approximately 3 percent of adrenal tumors and are commonly found in patients with congenital adrenal hyperplasia (CAH). CAH provides a unique environment to explore AML pathogenesis. We aimed to evaluate the role of the immune system and hormones that accumulate in poorly controlled CAH in the development of AML. When compared to normal adrenal tissue, CAH-affected adrenal tissue and myelolipomas showed an increased expression of inflammatory cells (

Indexed as

Adrenal Gland NeoplasmsAdrenal Hyperplasia, CongenitalLeukemia, Myeloid, AcuteLipomaMyelolipomaHumansadrenal myelolipomaB-lymphocytescell migrationcongenital adrenal hyperplasiainflammationRNA-sequencing

Identifiers

PMID38473790
PMCPMC10932011
OpenAlexW4392088667

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.