Evidence map›Paper›PMID 38473779›Full record

ArticleInternational journal of molecular sciences2024

The Vitamin C Enantiomers Possess a Comparable Potency in the Induction of Oxidative Stress in Cancer Cells but Differ in Their Toxicity.

Dinara Begimbetova, Agata N Burska, Aidana Baltabekova, Assiya Kussainova, Assiya Kukanova, Fatima Fazyl, Milana Ibragimova, Kenzhekyz Manekenova, Abay Makishev, Rakhmetkazhi I Bersimbaev and 1 more

Open access · goldAbstract read
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In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Dinara BegimbetovaNational Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.
Agata N BurskaNational Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.
Aidana BaltabekovaSchool of Medicine, Nazarbayev University, Astana 010000, Kazakhstan.
Assiya KussainovaNational Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0000-0002-1313-9779
Assiya KukanovaNational Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0000-0001-6775-2993
Fatima FazylNational Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.
Milana IbragimovaNational Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0009-0005-9425-3846
Kenzhekyz ManekenovaDepartment of Pathological Anatomy, Astana Medical University, Astana 010000, Kazakhstan.
Abay MakishevDepartment of Oncology, Astana Medical University, Astana 010000, Kazakhstan.
Rakhmetkazhi I BersimbaevDepartment of General Biology and Genomics, Institute of Cell Biology and Biotechnology, L.N. Gumilyov Eurasian National University, Astana 010008, Kazakhstan.
Dos D SarbassovNational Laboratory Astana, Nazarbayev University, Astana 010000, Kazakhstan.ORCID 0000-0002-6848-1133
Nazarbayev University · KZAstana Medical University · KZL. N. Gumilyov Eurasian National University · KZ

Funding

Ministry of Science and Higher Education of the Republic of Kazakhstan BR11765589Nazarbayev University 240919FD3904
6 · The paper itself

Abstract

The use of vitamin C (VC) in high doses demonstrates a potent tumor suppressive effect by mediating a glucose-dependent oxidative stress in Kirsten rat sarcoma (KRAS) mutant cancer cells. VC with arsenic trioxide (ATO) is a promising drug combination that might lead to the development of effective cancer therapeutics. Considering that a tumor suppressive effect of VC requires its high-dose administration, it is of interest to examine the toxicity of two enantiomers of VC (enantiomer d-optical isomer D-VC and natural l-optical isomer L-VC) in vitro and in vivo. We show that the combinations of L-VC with ATO and D-VC with ATO induced a similar cytotoxic oxidative stress in Kras

Indexed as

Ascorbic AcidNeoplasmsAnimalsArsenic TrioxideMiceOxidative StressProto-Oncogene Proteins p21(ras)VitaminsArsenic TrioxideAscorbic AcidProto-Oncogene Proteins p21(ras)VitaminsD-Isoascorbic acid (D-VC)L-ascorbic acid (L-VC)reactive oxidative species (ROS)toxicityvitamin C (VC) or ascorbic acid

Identifiers

PMID38473779
PMCPMC10931485
OpenAlexW4392052577

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.