Evidence map›Paper›PMID 38473765›Full record

ArticleInternational journal of molecular sciences2024

A Drug Discovery Approach to a Reveal Novel Antioxidant Natural Source: The Case of Chestnut Burr Biomass.

Alfonso Trezza, Michela Geminiani, Giuseppe Cutrera, Elena Dreassi, Luisa Frusciante, Stefania Lamponi, Ottavia Spiga, Annalisa Santucci

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Bioactive Potential of Sweet Cherry (Foods (Basel, Switzerland) · 2025
    Article
  5. Article
  6. Enhancing Industrial Hemp (International journal of molecular sciences · 2025
    Article
  7. Article
  8. Marine drugs · 2024
    Article
  9. Article
  10. RepurposingLife (Basel, Switzerland) · 2024
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alfonso TrezzaDepartment of Biotechnology Chemistry & Pharmacy, University of Siena, Via A. Moro, 53100 Siena, Italy.
Michela GeminianiDepartment of Biotechnology Chemistry & Pharmacy, University of Siena, Via A. Moro, 53100 Siena, Italy.ORCID 0000-0002-6910-0056
Giuseppe CutreraDepartment of Biotechnology Chemistry & Pharmacy, University of Siena, Via A. Moro, 53100 Siena, Italy.
Elena DreassiDepartment of Biotechnology Chemistry & Pharmacy, University of Siena, Via A. Moro, 53100 Siena, Italy.ORCID 0000-0001-8987-940X
Luisa FruscianteDepartment of Biotechnology Chemistry & Pharmacy, University of Siena, Via A. Moro, 53100 Siena, Italy.ORCID 0000-0002-4031-3066
Stefania LamponiDepartment of Biotechnology Chemistry & Pharmacy, University of Siena, Via A. Moro, 53100 Siena, Italy.ORCID 0000-0002-2788-8797
Ottavia SpigaDepartment of Biotechnology Chemistry & Pharmacy, University of Siena, Via A. Moro, 53100 Siena, Italy.ORCID 0000-0002-0263-7107
Annalisa SantucciDepartment of Biotechnology Chemistry & Pharmacy, University of Siena, Via A. Moro, 53100 Siena, Italy.ORCID 0000-0001-6976-9086

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Currently, many environmental and energy-related problems are threatening the future of our planet. In October 2022, the Worldmeter recorded the world population as 7.9 billion people, estimating that there will be an increase of 2 billion by 2057. The rapid growth of the population and the continuous increase in needs are causing worrying conditions, such as pollution, climate change, global warming, waste disposal, and natural resource reduction. Looking for novel and innovative methods to overcome these global troubles is a must for our common welfare. The circular bioeconomy represents a promising strategy to alleviate the current conditions using biomass-like natural wastes to replace commercial products that have a negative effect on our ecological footprint. Applying the circular bioeconomy concept, we propose an integrated in silico and in vitro approach to identify antioxidant bioactive compounds extracted from chestnut burrs (an agroforest waste) and their potential biological targets. Our study provides a novel and robust strategy developed within the circular bioeconomy concept aimed at target and drug discovery for a wide range of diseases. Our study could open new frontiers in the circular bioeconomy related to target and drug discovery, offering new ideas for sustainable scientific research aimed at identifying novel therapeutical strategies.

Indexed as

AntioxidantsClimate ChangeBiomassDrug DiscoveryEnvironmental PollutionHumansAntioxidantsantioxidantbioeconomychestnut burrdocking and molecular dynamics simulationdrug and target discoverymolecular modelingnatural bioproductpolyphenols

Identifiers

PMID38473765
PMCPMC10931234

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.