Evidence map›Paper›PMID 38473756›Full record

ArticleInternational journal of molecular sciences2024

Deep Flow Cytometry Unveils Distinct Immune Cell Subsets in Inducible T Cell Co-Stimulator Ligand (ICOSL)- and ICOS-Knockout Mice during Experimental Autoimmune Encephalomyelitis.

Davide Raineri, Hugo Abreu, Beatrice Vilardo, Natasa Kustrimovic, Chiara Venegoni, Giuseppe Cappellano, Annalisa Chiocchetti

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Davide RaineriDepartment of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, University of Eastern Piedmont, 28100 Novara, Italy.ORCID 0000-0003-3327-6305
Hugo AbreuDepartment of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, University of Eastern Piedmont, 28100 Novara, Italy.ORCID 0000-0003-4720-6519
Beatrice VilardoDepartment of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, University of Eastern Piedmont, 28100 Novara, Italy.ORCID 0000-0001-6431-9967
Natasa KustrimovicDepartment of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, University of Eastern Piedmont, 28100 Novara, Italy.ORCID 0000-0002-5524-5238
Chiara VenegoniDepartment of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, University of Eastern Piedmont, 28100 Novara, Italy.
Giuseppe CappellanoDepartment of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, University of Eastern Piedmont, 28100 Novara, Italy.ORCID 0000-0001-5193-4688
Annalisa ChiocchettiDepartment of Health Sciences, Interdisciplinary Research Center of Autoimmune Diseases-IRCAD, University of Eastern Piedmont, 28100 Novara, Italy.ORCID 0000-0002-4349-1087
Università degli Studi del Piemonte Orientale “Amedeo Avogadro” · IT

Funding

European Union 860462European Union 953121FISM 2020/PR-Single/021Ministry of Education, Universities and Research Departments of Excellence 2018-2022
6 · The paper itself

Abstract

The inducible T cell co-stimulator ligand (ICOSL), expressed by antigen presenting cells, binds to the inducible T cell co-stimulator (ICOS) on activated T cells. Improper function of the ICOS/ICOSL pathway has been implicated in several autoimmune diseases, including multiple sclerosis (MS). Previous studies showed that ICOS-knockout (KO) mice exhibit severe experimental autoimmune encephalomyelitis (EAE), the animal model of MS, but data on ICOSL deficiency are not available. In our study, we explored the impact of both ICOS and ICOSL deficiencies on MOG

Indexed as

Encephalomyelitis, Autoimmune, ExperimentalAnimalsFlow CytometryInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinLigandsMiceMice, Inbred C57BLMice, KnockoutT-LymphocytesInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinLigandsexperimental autoimmune encephalomyelitisICOSLmemory cellsmultiple sclerosisregulatory T cells

Identifiers

PMID38473756
PMCPMC10932052
OpenAlexW4392013516

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.