Evidence map›Paper›PMID 38473388›Full record

ReviewCancers2024

Current Status and Future Directions of Image-Guided Adaptive Brachytherapy for Locally Advanced Cervical Cancer.

Nicholas Eustace, Jason Liu, Colton Ladbury, Andrew Tam, Scott Glaser, An Liu, Yi-Jen Chen

Abstract readReview
In one paragraph

Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Brachytherapy use in cervical cancer: a narrative review.Gynecology and pelvic medicine · 2026
    Review
  5. Article
  6. Review
  7. Is model-based dose calculation based on cone-beam computed tomography suitable for adaptive treatment planning in brachytherapy?Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025
    Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Nicholas EustaceDepartment of Radiation Oncology, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, CA 91105, USA.
Jason LiuDepartment of Radiation Oncology, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, CA 91105, USA.ORCID 0000-0003-2287-2320
Colton LadburyDepartment of Radiation Oncology, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, CA 91105, USA.ORCID 0000-0002-2668-3415
Andrew TamDepartment of Radiation Oncology, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, CA 91105, USA.
Scott GlaserDepartment of Radiation Oncology, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, CA 91105, USA.
An LiuDepartment of Radiation Oncology, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, CA 91105, USA.
Yi-Jen ChenDepartment of Radiation Oncology, City of Hope National Medical Center, 1500 E Duarte Rd., Duarte, CA 91105, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe standard of care for patients with locally advanced cervical cancer is definitive chemoradiation followed by a brachytherapy boost. This review describes the current status and future directions of image-guided adaptive brachytherapy for locally advanced cervical cancer.

methodsA systematic search of the PubMed and Clinicaltrials.gov databases was performed, focusing on studies published within the last 10 years. The search queried "cervical cancer [AND] image-guided brachytherapy [OR] magnetic resonance imaging (MRI) [OR] adaptive brachytherapy". DISCUSSION: The retroEMBRACE and EMBRACE-I trials have established the use of MRI as the standard imaging modality for brachytherapy application and planning. Quantitative imaging and radiomics have the potential to improve outcomes, with three ongoing prospective studies examining the use of radiomics to further risk-stratify patients and personalize brachytherapy. Another active area of investigation includes utilizing the superior soft tissue contrast provided by MRI to increase the dose per fraction and decrease the number of fractions needed for brachytherapy, with several retrospective studies demonstrating the safety and feasibility of three-fraction courses. For developing countries with limited access to MRI, trans-rectal ultrasound (TRUS) appears to be an effective alternative, with several retrospective studies demonstrating improved target delineation with the use of TRUS in conjunction with CT guidance.

conclusionsFurther investigation is needed to continue improving outcomes for patients with locally advanced cervical cancer treated with image-guided brachytherapy.

Indexed as

adaptive brachytherapybrachytherapycervical cancerimage-guided brachytherapymagnetic resonance imagingultrasound-guided brachytherapy

Identifiers

PMID38473388
PMCPMC10931056

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.