Evidence map›Paper›PMID 38473359›Full record

ArticleCancers2024

Frontline and Relapsed Rhabdomyosarcoma (FaR-RMS) Clinical Trial: A Report from the European Paediatric Soft Tissue Sarcoma Study Group (EpSSG).

Julia Chisholm, Henry Mandeville, Madeleine Adams, Veronique Minard-Collin, Timothy Rogers, Anna Kelsey, Janet Shipley, Rick R van Rijn, Isabelle de Vries, Roelof van Ewijk and 17 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
17.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Guideline
  2. Trial
  3. Trial
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Whole Lung Irradiation in Rhabdomyosarcoma With Lung Metastases: A Report From the Soft Tissue Sarcoma Committee of the Children's Oncology Group.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024
    Article
  16. Orbital embryonal rhabdomyosarcoma: a case-based update.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 14 institutions in 6 countries.

Julia Chisholm *Children and Young People's Unit, Royal Marsden Hospital and Institute of Cancer Research, Sutton SM2 5PT, UK.ORCID 0000-0003-3479-7997
Henry Mandeville *Children and Young People's Unit, Royal Marsden Hospital and Institute of Cancer Research, Sutton SM2 5PT, UK.
Madeleine AdamsChildren's Hospital for Wales, Cardiff CF14 4XW, UK.
Veronique Minard-CollinDepartment of Paediatric Oncology, Gustave Roussy, 75015 Paris, France.
Timothy RogersDepartment of Paediatric Surgery, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol BS1 3NU, UK.ORCID 0000-0002-4499-0742
Anna KelseyDepartment of Paediatric Histopathology, Royal Manchester Children's Hospital, Manchester University NHS Foundation Trust, Manchester M13 9WL, UK.
Janet ShipleyThe Institute of Cancer Research, London SW7 3RP, UK.
Rick R van RijnDepartment of Radiology and Nuclear Medicine, University of Amsterdam, Amsterdam UMC, 1081 HV Amsterdam, The Netherlands.ORCID 0000-0002-8876-6515
Isabelle de VriesPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.ORCID 0000-0001-8289-4164
Roelof van EwijkPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.ORCID 0000-0003-0339-6031
Bart de KeizerPrincess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.ORCID 0000-0002-6270-9483
Susanne A GatzBirmingham Women's and Children's NHS Foundation Trust, Birmingham B15 2TG, UK.
Michela CasanovaFondazione IRCCS Istituto Nazionale Tumori, 20133 Milan, Italy.ORCID 0000-0003-0368-7883
Lisa Lyngsie HjalgrimUniversity Hospital Copenhagen, DK-2200 Copenhagen, Denmark.ORCID 0000-0001-5186-3365
Charlotte FirthCancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Keith WheatleyCancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Pamela KearnsCancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK.ORCID 0000-0003-2756-5813
Wenyu LiuCancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Amanda KirkhamCancer Research UK Clinical Trials Unit, Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Helen ReesDepartment of Paediatric Oncology, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol BS1 3NU, UK.
Gianni BisognoDepartment of Women and Children's Health, University of Padova, 35122 Padua, Italy.ORCID 0000-0003-4462-5523
Ajla WastiThe Institute of Cancer Research, London SW7 3RP, UK.
Sara WakelingAlice's Arc Charity, London EC1V 1AW, UK.ORCID 0000-0002-3563-0390
Delphine HeenenKickCancer Foundation, 1000 Brussels, Belgium.ORCID 0000-0002-7703-9902
Deborah A TweddleVivo Biobank, Translational & Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.ORCID 0000-0003-2208-3970
Johannes H M Merks *Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands.ORCID 0000-0001-7659-1028
Meriel Jenney *Children's Hospital for Wales, Cardiff CF14 4XW, UK.
Cancer Research UK Clinical Trials Unit · GBPrincess Máxima Center · NLInstitute of Cancer Research · GBNoah's Ark Children's Hospital for Wales · GBRoyal Marsden NHS Foundation Trust · GBUniversity Hospitals Bristol NHS Foundation Trust · GBAmsterdam University Medical Centers · NLAnticancer Fund · BECopenhagen University Hospital · DKFondazione IRCCS Istituto Nazionale dei Tumori · ITInstitut Gustave Roussy · FRManchester University NHS Foundation Trust · GBNewcastle University · GBUniversity of Padua · IT

Funding

Cancer Research UK 28028Cancer Research UK CRUK/17/011
6 · The paper itself

Abstract

The Frontline and Relapsed Rhabdomyosarcoma (FaR-RMS) clinical trial is an overarching, multinational study for children and adults with rhabdomyosarcoma (RMS). The trial, developed by the European Soft Tissue Sarcoma Study Group (EpSSG), incorporates multiple different research questions within a multistage design with a focus on (i) novel regimens for poor prognostic subgroups, (ii) optimal duration of maintenance chemotherapy, and (iii) optimal use of radiotherapy for local control and widespread metastatic disease. Additional sub-studies focusing on biological risk stratification, use of imaging modalities, including [

Indexed as

chemotherapyclinical trialEpSSGFaR-RMSnovel agentsradiotherapyrandomisationrhabdomyosarcoma

Identifiers

PMID38473359
PMCPMC10931395
OpenAlexW4392295951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.