ReviewCancers2024
Pathogenesis of Warthin's Tumor: Neoplastic or Non-Neoplastic?
Review in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 15 citations in OpenAlex.
- TRP matters: a pilot study on expression of mRNA in the parotid glands and their benign tumors.Biochemistry and biophysics reports · 2026Article
- Pathogenesis of Warthin's Tumors: A Critical Synthesis of the Evidence.Head and neck pathology · 2026Review
- Epidemiological Characterizations and Diagnostic Strategies Variation in Parotid Gland Tumors (2010-2024): Observations Based on 2133 Cases.Cancer medicine · 2026Article
- Characterizing Warthin-Like Mucoepidermoid Carcinoma: Clinicopathologic Features and MAML2 Rearrangements in 14 Latin American Cases.Head and neck pathology · 2026Article
- Diagnostic value of the pan-immune-inflammation value, plateletcrit, and monocyte count in salivary gland tumors: a 10-year two-stage retrospective analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- A comprehensive model with dual plane ultrasound based deep learning radiomics to distinguish parotid pleomorphic adenoma from Warthin tumor.Frontiers in oncology · 2026Article
- Benign Epithelial Salivary Neoplasms: Single-Centered Histopathologic and Clinicodemographic Romanian Retrospective Study.Clinics and practice · 2025Article
- Multimodality Imaging of Warthin's Tumor: PET/CT, Scintigraphy, MRI, and CT.Diagnostics (Basel, Switzerland) · 2025Article
- Differential expression of haematopoietic prostaglandin D synthase by POU2F3‑positive tuft cells in conventional bilayered oncocytic and metaplastic epithelia of Warthin tumours.Molecular medicine reports · 2025Article
- Pleomorphic adenoma with extensive oncocytic change in the parotid gland: a case report and review.Gland surgery · 2025Article
- Case Report: Sebaceous lymphadenocarcinoma arising in parotid gland: eighth documented case with lymph node metastasis.Frontiers in oncology · 2025Article
- Development and evaluation of a clinical-biochemical nomogram for differentiating pleomorphic adenoma and Warthin's tumor in the parotid gland.Frontiers in oncology · 2025Article
- Nomogram combining dual-energy computed tomography features and radiomics for differentiating parotid warthin tumor from pleomorphic adenoma: a retrospective study.Frontiers in oncology · 2025Article
- Could Obesity Be Related to the Increasing Incidence of Warthin Tumors?Journal of clinical medicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Warthin's tumor is the second most frequent neoplasm next to pleomorphic adenoma in the salivary gland, mostly in the parotid gland. The epithelial cells constituting a tumor are characterized by the presence of mitochondria that undergo structural and functional changes, resulting in the development of oncocytes. In addition to containing epithelial cells, Warthin's tumors contain abundant lymphocytes with lymph follicles (germinal centers) that are surrounded by epithelial cells. The pathogenesis of Warthin's tumor is not fully understood, and several hypotheses have been proposed. The risk factors for the development of Warthin's tumor, which predominantly occurs in males, include aging, smoking, and radiation exposure. Recently, it has been reported that chronic inflammation and aging cells promote the growth of Warthin's tumor. Several reports regarding the origin of the tumor have suggested that (1) Warthin's tumor is an IgG4-related disease, (2) epithelial cells that compose Warthin's tumor accumulate mitochondria, and (3) Warthin's tumor is a metaplastic lesion in the lymph nodes. It is possible that the pathogenesis of Warthin's tumor includes mitochondrial metabolic abnormalities, accumulation of aged cells, chronic inflammation, and senescence-associated secretory phenotype (SASP). In this short review, we propose that DNA damage, metabolic dysfunction of mitochondria, senescent cells, SASP, human papillomavirus, and IgG4 may be involved in the development of Warthin's tumor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.