Evidence map›Paper›PMID 38473223›Full record

ArticleCancers2024

Development and Optimisation of Tumour Treating Fields (TTFields) Delivery within 3D Primary Glioma Stem Cell-like Models of Spatial Heterogeneity.

Callum G Jones, Aurelie Vanderlinden, Ola Rominiyi, Spencer J Collis

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Callum G JonesDivision of Clinical Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK.ORCID 0000-0003-2958-8322
Aurelie VanderlindenDivision of Clinical Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK.
Ola RominiyiDivision of Clinical Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK.ORCID 0000-0002-9724-0224
Spencer J CollisDivision of Clinical Medicine, University of Sheffield Medical School, Sheffield S10 2RX, UK.ORCID 0000-0002-7874-1891

Funding

American Association For Cancer Research 21-60-62-COLLBrain Tumour Charity GN-000715
6 · The paper itself

Abstract

Glioblastoma is an aggressive, incurable brain cancer with poor five-year survival rates of around 13% despite multimodal treatment with surgery, DNA-damaging chemoradiotherapy and the recent addition of Tumour Treating Fields (TTFields). As such, there is an urgent need to improve our current understanding of cellular responses to TTFields using more clinically and surgically relevant models, which reflect the profound spatial heterogeneity within glioblastoma, and leverage these biological insights to inform the rational design of more effective therapeutic strategies incorporating TTFields. We have recently reported the use of preclinical TTFields using the inovitro

Indexed as

3D modelsDNA damage response inhibitorsglioblastomaglioma stem-like cellsstandard-of-care therapiesTTFieldsTumour Treating Fields

Identifiers

PMID38473223
PMCPMC10930697

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.