ReviewDiagnostics (Basel, Switzerland)2024
Lower Rates of Hypocalcemia Following Near-Infrared Autofluorescence Use in Thyroidectomy: A Meta-Analysis of RCTs.
Review in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Indocyanine green (ICG) guided thyroidectomy versus conventional thyroidectomy and the impact on parathyroid function preservation: an updated GRADE-assessed systematic review and meta-analysis.Langenbeck's archives of surgery · 2026Pooled it
- Efficacy and role of indocyanine green angiography in thyroidectomy: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- Impact of Intraoperative Interventions on Hypocalcemia Post-Total Thyroidectomy: A Meta-Analysis.Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-facialePooled it
- A Simple Technique for Probe-Based NIRAF-Guided Parathyroid Identification in TOETVA.The Laryngoscope · 2026Article
- Does parathyroid autofluorescence reduces unintentional parathyroidectomy during total thyroidectomy with central lymph node compartment dissection?Updates in surgery · 2026Article
- Enhanced parathyroid identification and preservation in total thyroidectomy using combined near-infrared autofluorescence and carbon nanoparticles.Frontiers in surgery · 2026Article
- Autofluorescence enhances intraoperative detection of parathyroid glands: a single-center comparative study.Frontiers in endocrinology · 2026Article
- Article
- Protection of parathyroid function during thyroid surgery with a complete intermediate approach: a retrospective multicenter observational study.BMC cancer · 2025Observational
- Advancing parathyroid surgery: a critical examination of probe-based near-infrared autofluorescence technology.Gland surgery · 2024Article
- Editorial: 2023 symposium on parathyroid fluorescence.Frontiers in endocrinology · 2024Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIatrogenic injury of the parathyroid glands is the most frequent complication after total thyroidectomy.
objectiveTo determine the effectiveness of near-infrared autofluorescence (NIRAF) in reducing postoperative hypocalcemia following total thyroidectomy.
methodsPubMed, Scopus, and Google Scholar databases were searched. Randomised trials reporting at least one hypocalcemia outcome following total thyroidectomy using NIRAF were included.
resultsThe qualitative data synthesis comprised 1363 patients from nine randomised studies, NIRAF arm = 636 cases and non-NIRAF arm = 637 cases. There was a statistically significant difference in the overall rate of hypocalcemia log(OR) = -0.7 [(-1.01, -0.40), M-H, REM, CI = 95%] and temporary hypocalcemia log(OR) = -0.8 [(-1.01, -0.59), M-H, REM, CI = 95%] favouring the NIRAF. The difference in the rate of permanent hypocalcemia log(OR) = -1.09 [(-2.34, 0.17), M-H, REM, CI = 95%] between the two arms was lower in the NIRAF arm but was not statistically significant.
conclusionsNIRAF during total thyroidectomy helps in reducing postoperative hypocalcemia. Level of evidence-1.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.