Evidence map›Paper›PMID 38472812›Full record

ArticleFoods (Basel, Switzerland)2024

High-Fat Diet-Induced Decreased Circulating Bile Acids Contribute to Obesity Associated with Gut Microbiota in Mice.

Haiying Cai, Junhui Zhang, Chang Liu, Thanh Ninh Le, Yuyun Lu, Fengqin Feng, Minjie Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Foods (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
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  6. A Synbiotic of Lacto-Nutrients · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Haiying CaiSchool of Biological and Chemical Engineering, Zhejiang University of Science & Technology, Hangzhou 310023, China.
Junhui ZhangCollege of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-3599-2682
Chang LiuSchool of Biological and Chemical Engineering, Zhejiang University of Science & Technology, Hangzhou 310023, China.
Thanh Ninh LeDepartment of Food Science and Technology, National University of Singapore, Singapore 117542, Singapore.ORCID 0000-0001-9812-2345
Yuyun LuDepartment of Food Science and Technology, National University of Singapore, Singapore 117542, Singapore.ORCID 0000-0003-3977-0603
Fengqin FengCollege of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-9770-1721
Minjie ZhaoCollege of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-5429-9824
National University of Singapore · SGZhejiang University · CNZhejiang University of Science and Technology · CN

Funding

National Natural Science Foundation of China 31972079, 32172214 32001693
6 · The paper itself

Abstract

The altered circulating bile acids (BAs) modulate gut microbiota, energy metabolism and various physiological functions. BA profiles in liver, serum, ileum and feces of HFD-fed mice were analyzed with normal chow diet (NCD)-fed mice after 16-week feeding. Furthermore, gut microbiota was analyzed and its correlation analysis with BA was performed. The result showed that long-term HFD feeding significantly decreased hepatic and serum BA levels, mainly attributed to the inhibition of hepatic BA synthesis and the reduced reabsorption efficiency of BAs in enterohepatic circulation. It also significantly impaired glucose and lipid homeostasis and gut microbiota in mice. We found significantly higher bile salt hydrolase activity in ileal microbes and a higher ratio of free BAs to conjugated BA content in ileal contents in HFD groups compared with NCD group mice, which might account for the activated intestinal farnesoid X receptor signaling on liver BA synthesis inhibition and reduced ileal reabsorption. The decreased circulating BAs were associated with the dysregulation of the lipid metabolism according to the decreased TGR5 signaling in the ileum and BAT. In addition, it is astonishing to find extremely high percentages of taurocholate and 12-OH BAs in liver and serum BA profiles of both groups, which was mainly attributed to the high substrate selectivity for 12-OH BAs of the intestinal BAs transporter during the ileal reabsorption of enterohepatic circulation. This study revealed a significant effect of long-term HFD feeding on the decreased circulating BA pool in mice, which impaired lipid homeostasis and gut microbiota, and collectively resulted in metabolic disorders and obesity.

Indexed as

bile acidsgut microbiotahigh-fat dietlipid homeostasisobesity

Identifiers

PMID38472812
PMCPMC10931208
OpenAlexW4392169514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.