Evidence map›Paper›PMID 38472656›Full record

ArticleCell biology and toxicology2024

The mitochondrial UPR induced by ATF5 attenuates intervertebral disc degeneration via cooperating with mitophagy.

Wen-Ning Xu, Huo-Liang Zheng, Run-Ze Yang, Yuan-Fang Sun, Bi-Rong Peng, Chun Liu, Jian Song, Sheng-Dan Jiang, Li-Xin Zhu

Open access · hybridAbstract read
In one paragraph

Article in Cell biology and toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Wen-Ning Xu *Department of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.
Huo-Liang Zheng *Department of Clinic of Spine Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200082, China.
Run-Ze Yang *Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, China.
Yuan-Fang SunDepartment of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.
Bi-Rong PengDepartment of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.
Chun LiuDepartment of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.
Jian SongDepartment of Clinic of Spine Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200082, China. 16111220046@fudan.edu.cn.
Sheng-Dan JiangDepartment of Clinic of Spine Center, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200082, China. jiangshengdan@xinhuamed.com.cn.
Li-Xin ZhuDepartment of Spinal Surgery, Orthopedic Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China. zhulixin1966@163.com.
Southern Medical University · CNXinHua Hospital · CNZhujiang Hospital · CNHuashan Hospital · CNWest China Hospital of Sichuan University · CN

Funding

China Postdoctoral Science Foundation 2021M701630Guangzhou Science and Technology Plan Project 202201011451National Natural Science Foundation of China 81672206National Natural Science Foundation of China 81974329National Natural Science Foundation of China 82302721Shanghai Rising-Star Program 20YF1429900
6 · The paper itself

Abstract

Intervertebral disc degeneration (IVDD) is an aging disease that results in a low quality of life and heavy socioeconomic burden. The mitochondrial unfolded protein response (UPR

Indexed as

Intervertebral Disc DegenerationMitophagyActivating Transcription FactorsAnimalsApoptosisCyclic AMP Response Element-Binding ProteinHumansMitochondriaProtein KinasesQuality of LifeRatsRats, Sprague-DawleyActivating Transcription FactorsATF5 protein, humanAtf5 protein, mouseCyclic AMP Response Element-Binding ProteinProtein KinasesAtf5Intervertebral disc degenerationMitochondrial unfolded protein responseMitophagyPink1

Identifiers

PMID38472656
PMCPMC10933207
OpenAlexW4392755192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.