Observational studyEuropean radiology experimental2024
Repeatability of deuterium metabolic imaging of healthy volunteers at 3 T.
Observational study in European radiology experimental, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05402566 (MRI Assessment of Impaired Glucose Metabolism in Alzheimer's Disease), which is not on this map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MRI Assessment of Impaired Glucose Metabolism in Alzheimer's Disease
Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Physics-embedded CycleGAN for robust metabolite mapping in short-readout deuterium metabolic imaging.Magnetic resonance letters · 2026Article
- From equilibrium to dynamic metabolic imaging: the evolving role of magnetic resonance spectroscopic imaging in neurodegenerative disorders.Journal of translational medicine · 2026Review
- Atlas of Brain Glucose Metabolism Using Deuterium Metabolic Imaging at 3 T.Magnetic resonance in medicine · 2026Article
- Advanced methods in deuterium metabolic imaging.Magma (New York, N.Y.) · 2026Review
- Absolute Quantification of Brain Deuterium Metabolic Imaging in Healthy Volunteers and Glioblastoma Patients at 7T.Magnetic resonance in medicine · 2026Article
- Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas.Science translational medicine · 2026Article
- Review
- Deuterium Metabolic Imaging of the Human Abdomen at Clinical Field Strength.Investigative radiology · 2026Article
- Advancing Deuterium MRI to Track Human Cerebral Glucose Metabolism at 7 T: A Comparison of Glucose-dNMR in biomedicine · 2025Article
- Comparison of Low-Rank Denoising Methods for Dynamic Deuterium MRSI at 7 T.NMR in biomedicine · 2025Article
- Open-source implementation of X-nuclear sequences using the Pulseq framework.Magnetic resonance in medicine · 2025Article
- PyAMARES, an Open-Source Python Library for Fitting Magnetic Resonance Spectroscopy Data.Diagnostics (Basel, Switzerland) · 2024Article
- Test-Retest Reproducibility of Reduced-Field-of-View Density-Weighted CRT MRSI at 3T.Tomography (Ann Arbor, Mich.) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMagnetic resonance (MR) imaging of deuterated glucose, termed deuterium metabolic imaging (DMI), is emerging as a biomarker of pathway-specific glucose metabolism in tumors. DMI is being studied as a useful marker of treatment response in a scan-rescan scenario. This study aims to evaluate the repeatability of brain DMI.
methodsA repeatability study was performed in healthy volunteers from December 2022 to March 2023. The participants consumed 75 g of [6,6'-
resultsSix male participants were recruited, aged 34 ± 6.5 years (mean ± standard deviation). There was 42 ± 2.7 days between sessions. Whole-brain levels of glutamine + glutamate, lactate, and glucose increased to 3.22 ± 0.4 mM, 1.55 ± 0.3 mM, and 3 ± 0.7 mM, respectively. The best signal-to-noise ratio and repeatability was obtained at the 120-min timepoint. Here, the within-subject whole-brain CoVs were -10% for all metabolites, while the between-subject CoVs were -20%.
conclusionsDMI of glucose and its downstream metabolites is feasible and repeatable on a clinical 3 T system.
trial registrationClinicalTrials.gov, NCT05402566 , registered the 25th of May 2022. RELEVANCE STATEMENT: Brain deuterium metabolic imaging of healthy volunteers is repeatable and feasible at clinical field strengths, enabling the study of shifts in tumor metabolism associated with treatment response. KEY POINTS: • Deuterium metabolic imaging is an emerging tumor biomarker with unknown repeatability. • The repeatability of deuterium metabolic imaging is on par with FDG-PET. • The study of deuterium metabolic imaging in clinical populations is feasible.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.