Evidence map›Paper›PMID 38472602›Full record

ArticleAnnals of biomedical engineering2024

Poroelastic Characterization and Modeling of Subcutaneous Tissue Under Confined Compression.

Jacques Barsimantov, Jordanna Payne, Mario de Lucio, Mazin Hakim, Hector Gomez, Luis Solorio, Adrian B Tepole

Abstract read
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In one paragraph

Article in Annals of biomedical engineering, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Nonmonotonic rate-dependent adhesion of hydrogels.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jacques BarsimantovSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Jordanna PayneWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Mario de LucioSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Mazin HakimWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Hector GomezSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA.
Luis SolorioWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Adrian B TepoleSchool of Mechanical Engineering, Purdue University, West Lafayette, IN, USA. abuganza@purdue.edu.ORCID http://orcid.org/0000-0001-8531-0603
Purdue University West Lafayette · US

Funding

Eli Lilly and Company Eli Lilly - Purdue Partnership
6 · The paper itself

Abstract

Subcutaneous tissue mechanics are important for drug delivery. Yet, even though this material is poroelastic, its mechanical characterization has focused on its hyperelastic response. Moreover, advancement in subcutaneous drug delivery requires effective tissue mimics such as hydrogels for which similar gaps of poroelastic data exist. Porcine subcutaneous samples and gelatin hydrogels were tested under confined compression at physiological conditions and strain rates of 0.01%/s in 5% strain steps with 2600 s of stress relaxation between loading steps. Force-time data were used in an inverse finite element approach to obtain material parameters. Tissues and gels were modeled as porous neo-Hookean materials with properties specified via shear modulus, effective solid volume fraction, initial hydraulic permeability, permeability exponent, and normalized viscous relaxation moduli. The constitutive model was implemented into an isogeometric analysis (IGA) framework to study subcutaneous injection. Subcutaneous tissue exhibited an initial spike in stress due to compression of the solid and fluid pressure buildup, with rapid relaxation explained by fluid drainage, and longer time-scale relaxation explained by viscous dissipation. The inferred parameters aligned with the ranges reported in the literature. Hydraulic permeability, the most important parameter for drug delivery, was in the range

Indexed as

HydrogelsModels, BiologicalSubcutaneous TissueAnimalsCompressive StrengthElasticityFinite Element AnalysisGelatinPorosityStress, MechanicalSwineGelatinHydrogelsConfined compressionIsogeometric analysisNonlinear finite elementsPoroelasticitySubcutaneous tissue

Identifiers

PMID38472602
OpenAlexW4392683343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.