Evidence map›Paper›PMID 38472520›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2024

Host-parasite interaction in severe and uncomplicated malaria infection in ghanaian children.

Richard H Asmah, Daniel Sai Squire, Selorme Adupko, David Adedia, Eric Kyei-Baafour, Ebenezer K Aidoo, Patrick F Ayeh-Kumi

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Richard H Asmah *Department of Biomedical Sciences, School of Basic and Biomedical Sciences, University of Health and Allied Sciences, Ho, Ghana.
Daniel Sai Squire *Department of Medical Laboratory Science, School of Allied Health Sciences, University of Health and Allied Sciences, Ho, Volta Region, Ghana. dsquire@uhas.edu.gh.ORCID http://orcid.org/0000-0001-9139-4882
Selorme AdupkoDepartment of Pharmaceutics and Microbiology, School of Pharmacy, University of Ghana, Accra, Ghana.
David AdediaDepartment of Basic Sciences, School of Basic and Biomedical Sciences, University of University of Health and Allied Sciences, Ho, Ghana.
Eric Kyei-BaafourDepartment of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Ebenezer K AidooDepartment of Medical Laboratory Technology, Accra Technical University, Accra, Ghana.
Patrick F Ayeh-KumiDepartment of Medical Microbiology, University of Ghana Medical School, Accra, Ghana.
University of Ghana · GHUniversity of Health and Allied Sciences · GHAccra Technical University · GH

Funding

University of Ghana Research Fund No. URF/4/007/2011-2012)
6 · The paper itself

Abstract

purposeDuring malarial infection, both parasites and host red blood cells (RBCs) come under severe oxidative stress due to the production of free radicals. The host system responds in protecting the RBCs against the oxidative damage caused by these free radicals by producing antioxidants. In this study, we investigated the antioxidant enzyme; superoxide dismutase (SOD) activity and cytokine interactions with parasitaemia in Ghanaian children with severe and uncomplicated malaria. METHODOLOGY: One hundred and fifty participants aged 0-12 years were administered with structured questionnaires. Active case finding approach was used in participating hospitals to identify and interview cases before treatment was applied. Blood samples were taken from each participant and used to quantify malaria parasitaemia, measure haematological parameters and SOD activity. Cytokine levels were measured by commercial ELISA kits. DNA comet assay was used to evaluate the extent of parasite DNA damage due to oxidative stress.

resultsSeventy - Nine (79) and Twenty- Six (26) participants who were positive with malaria parasites were categorized as severe (56.75 × 10

conclusionCritical roles played by SOD activity and cytokines as anti-parasitic defense during P. falciparum malaria infection in children were established.

Indexed as

CytokinesHost-Parasite InteractionsOxidative StressParasitemiaChildChild, PreschoolDNA DamageFemaleGhanaHumansInfantInfant, NewbornMalariaMalaria, FalciparumMalePlasmodium falciparumCytokinesSuperoxide DismutaseCytokinesGhanaian childrenHost-parasite interactionMalariaPlasmodium FalciparumSevereSuperoxide dismutaseUncompleted

Identifiers

PMID38472520
OpenAlexW4392691781

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.