Evidence map›Paper›PMID 38472511›Full record

ArticleBiological trace element research2025

Ameliorative effect of Ononis natrix against chronic lead poisoning in mice: neurobehavioral, biochemical, and histological study.

Asmaa Haj-Khlifa, Faissal Aziz, Maroua Ait Tastift, Souad Sellami, Hanane Rais, Miloud Hammoud, Naima Fdil, Najib Kissani, Halima Gamrani, Moulay Mustapha Bouyatas

Abstract read
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In one paragraph

Article in Biological trace element research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.5field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 8 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Asmaa Haj-KhlifaNeuroscience, Pharmacology and Environment Unit (ENPE), Departement of Biology, Faculty of Sciences Semlalia,, Cadi Ayyad University, 40000, Marrakech, Morocco.
Faissal AzizLaboratory of Water, Biodiversity, and Climate Change, Faculty of Sciences Semlalia, Cadi Ayyad University, 2390, 40000, Marrakech, BP, Morocco.
Maroua Ait TastiftLaboratory of Agri-Food, Biotechnology, and Valorization of Plant Resources, Phytochemistry and Pharmacology of Medicinal Plants Unit, Faculty of Sciences Semlalia, Cadi Ayyad University, Avenue Prince Moulay Abdellah, 40000, Marrakech, BP 2390, Morocco.
Souad SellamiMohammed VI University Hospital, Marrakech, Morocco.
Hanane RaisMohammed VI University Hospital, Marrakech, Morocco.
Miloud HammoudMetabolics Platform, Biochemistry Laboratory, Faculty of Medicine, Cadi Ayyad University, Sidi Abbad, 40000, Marrakech, BP, Morocco.
Naima FdilMetabolics Platform, Biochemistry Laboratory, Faculty of Medicine, Cadi Ayyad University, Sidi Abbad, 40000, Marrakech, BP, Morocco.
Najib KissaniLaboratory of Clinical and Experimental Neurosciences and Environment, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
Halima Gamrani *Neuroscience, Pharmacology and Environment Unit (ENPE), Departement of Biology, Faculty of Sciences Semlalia,, Cadi Ayyad University, 40000, Marrakech, Morocco. gamrani54@gmail.com.
Moulay Mustapha Bouyatas *Neuroscience, Pharmacology and Environment Unit (ENPE), Departement of Biology, Faculty of Sciences Semlalia,, Cadi Ayyad University, 40000, Marrakech, Morocco. m.bouyatas@uca.ma.
Cadi Ayyad University · MACentre Hospitalier Universitaire Mohammed VI · MA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lead (Pb) is one of the most common heavy metals with toxicological effects on many tissues in humans as well as animals. In order to counteract the toxic effects of this metal, the administration of synthetic or natural antioxidants is thus required. The aim of this study was to examine the beneficial effect of the aqueous extract of Ononis natrix (AEON) against lead acetate-induced damage from a behavioral, biochemical, and histological point of view. Forty-eight male mice were divided into four equal groups: Ctr (control); Pb (lead acetate 1g/l); Pb + On 100 mg/kg (lead acetate 1 g/l + AEON 100 mg/kg); Pb + On 500 mg/kg (lead acetate 1 g/l + AEON 500 mg/kg). AEON was administered orally from day 21 after the start of lead exposure up to the end of the experiment. The results revealed that lead induced behavioral disorders, increased serum levels of liver markers (AST, ALT, and bilirubin), as well as kidney markers (urea and creatinine). At the same time, levels of thiobarbituric acid reactive substances (TBARS) and glutathione peroxidase (GPx) increased significantly. Moreover, Pb caused structural changes in the liver and kidneys of Pb-exposed mice. However, AEON administration significantly improved all lead-induced brain, liver, and kidney dysfunctions. Our results suggest that AEON could be a source of molecules with therapeutic potential against brain, liver, and kidney abnormalities caused by lead exposure.

Indexed as

Lead PoisoningPlant ExtractsAnimalsAntioxidantsBehavior, AnimalKidneyLeadLiverMaleMiceOrganometallic CompoundsAntioxidantsLeadlead acetateOrganometallic CompoundsPlant ExtractsBehaviorBiochemical analysesChronic lead toxicityHistopathologyMiceOnonis natrix

Identifiers

PMID38472511
OpenAlexW4392682450

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.