Evidence map›Paper›PMID 38472437›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Health-related quality of life over chemotherapy course among individuals with early-stage breast cancer: the association of social determinants of health and neighborhood socioeconomic disadvantage.

Kai-Lin You, Susan M Sereika, Catherine M Bender, Jill B Hamilton, Susan R Mazanec, Adam Brufsky, Margaret Quinn Rosenzweig

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. L-SOLCO Pilot Study: Examining Allostatic Load and Cancer Treatment Disparities.Journal of racial and ethnic health disparities · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kai-Lin YouSchool of Nursing, University of Pittsburgh, 3500 Victoria Street, Pittsburgh, PA, USA. kailinyou@pitt.edu.
Susan M SereikaSchool of Nursing, University of Pittsburgh, 3500 Victoria Street, Pittsburgh, PA, USA.
Catherine M BenderSchool of Nursing, University of Pittsburgh, 3500 Victoria Street, Pittsburgh, PA, USA.
Jill B HamiltonNell Hodgson Woodruff School of Nursing, Emory University, Atlanta, GA, USA.
Susan R MazanecFrances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
Adam BrufskyDivision of Hematology/Oncology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Margaret Quinn RosenzweigSchool of Nursing, University of Pittsburgh, 3500 Victoria Street, Pittsburgh, PA, USA.
University of Pittsburgh · USCase Western Reserve University · USEmory University · US

Funding

The Symptom Experience, Management and Outcomes According to Race and Social Determinants of Health (SEMOARS) during Breast Cancer ChemotherapyR01MD012245 · NIMHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ROSENZWEIG, MARGARET Q. · 2017 to 2021
$3.3M
NIMHD NIH HHS 1R01MD012245-01NIMHD NIH HHS R01 MD012245
6 · The paper itself

Abstract

purposeThis study aimed to examine relationships between health-related quality of life (HRQOL), social determinants of health, and neighborhood socioeconomic disadvantage in individuals with early-stage breast cancer (ESBC) during chemotherapy.

methodsThis is a longitudinal study that recruited Black and White women with ESBC receiving chemotherapy. Participants completed questionnaires recording their sociodemographic information at baseline and the Functional Assessment of Cancer Therapy-General (FACT-G) to report their HRQOL before each chemotherapy cycle. Linear mixed modeling was employed to examine the associations between FACT-G scores, self-reported race, and area deprivation index (ADI) before and at the last chemotherapy cycle, with the duration of chemotherapy treatment as a covariate.

resultsA total of 84 Black and 146 White women with ESBC completed the surveys. Linear mixed modeling results suggested that women with ESBC who reported being Black experienced significantly worse physical well-being than those who reported being White throughout chemotherapy, with a 0.22-point lower average (p = 0.02). Both Black and White women with ESBC experienced decreased functional well-being over the chemotherapy, and Black women consistently reported lower scores than White women, with the change in functional well-being over time differing between racial groups (p = 0.03). Participants' ADI national percentiles were not significantly associated with their HRQOL throughout chemotherapy.

conclusionsThese findings underscore possible racial differences in some dimensions of HRQOL during chemotherapy among women with ESBC. Future research should consider further assessing life stressors and past experiences of discrimination and racism that may contribute to these disparities and guide proactive interventions.

Indexed as

Breast NeoplasmsQuality of LifeFemaleHumansLongitudinal StudiesSocial Determinants of HealthSocioeconomic Disparities in HealthBreast cancerDisparitiesHealth-related quality of lifeSocial determinants of health

Identifiers

PMID38472437
PMCPMC11966742
OpenAlexW4394767276

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.