SynthesisEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2024
The significance of heterotopic ossification following total ankle arthroplasty: a systematic review and meta-analysis.
Synthesis in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07732153 (Survival, Clinical and Radiological Outcomes of Total Ankle Arthroplasty With Lateral Transfibular Approach With a Minimum 10 Years Follow up), which is not on this map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Survival, Clinical and Radiological Outcomes of Total Ankle Arthroplasty With Lateral Transfibular Approach With a Minimum 10 Years Follow up
Who cites it
5 citing papers in PubMed, 4 citations in OpenAlex.
- Heterotopic ossifications following an anterior approach total ankle arthroplasty: incidence, distribution, and correlation with rehabilitation.Musculoskeletal surgery · 2026Article
- Use of an Extended-Length Tibial Tray in Total Ankle Arthroplasty: Rate of Subsidence, Loosening, Heterotopic Bone Formation, and Clinical Outcomes.Foot & ankle orthopaedics · 2026Article
- Diagnostic Imaging and Clinical Implications of Heterotopic Ossification After Total Ankle Arthroplasty: A Systematic Review for Surgical Strategy.Diagnostics (Basel, Switzerland) · 2025Review
- Indications, Functional Outcomes, Return to Sport and Complications of Anterior and Lateral Approaches for Total Ankle Arthroplasty: A Comprehensive Review.Healthcare (Basel, Switzerland) · 2025Review
- Celecoxib as Heterotopic Ossification Prophylaxis in Total Ankle Arthroplasty: A Retrospective Cohort Study.Foot & ankle orthopaedics · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this systematic review and meta-analysis was to evaluate the prevalence and clinical significance of heterotopic ossification (HO) following total ankle replacement (TAR).
methodsDuring August 2023, the PubMed, Embase and Cochrane library databases were systematically reviewed to identify clinical studies reporting HO following TAR. Data regarding surgical characteristics, pathological characteristics, subjective clinical outcomes, ankle range of motion, radiographic outcomes, reoperation rates were extracted and analysed.
resultsTwenty-seven studies with 2639 patients (2695 ankles) at a weighed mean follow-up time of 52.8 ± 26.9 months were included. The pooled prevalence rate was 44.6% (0.25; 0.66). The implant with the highest rate of HO was the INBONE I (100%) and BOX (100%) implants. The most common modified Brooker staging was grade 1 (132 patients, 27.0%). Random effects models of standardized mean differences found no difference in American orthopedic foot and ankle society (AOFAS) scores, visual analog scale scores (VAS) and ankle range of motion (ROM) between patients with HO and patients without HO. Random effects models of correlation coefficients found no correlation between AOFAS, VAS and ROM and the presence of HO. The surgical intervention rate for symptomatic HO was 4.2%.
conclusionThis systematic review and meta-analysis found that HO is a common finding following TAR that is not associated with inferior clinical outcomes. Surgical intervention was required only for moderate-to-severe, symptomatic HO following TAR. This study is limited by the marked heterogeneity and low level and quality of evidence of the included studies. Further higher quality studies are warranted to determine the precise prevalence and impact of HO on outcomes following TAR. LEVEL OF EVIDENCE III:
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