ReviewCellular and molecular life sciences : CMLS2024
Glymphatic-lymphatic coupling: assessment of the evidence from magnetic resonance imaging of humans.
Review in Cellular and molecular life sciences : CMLS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Rethinking lumbar puncture safety: pathophysiology, diagnostic uncertainty, and research gaps in herniation risk.Acta neurologica Belgica · 2026Pooled it
- How brain pulsations drive solute transport in the cranial subarachnoid space: insights from a toy model.Journal of the Royal Society, Interface · 2026Article
- Article
- High frame ratebioRxiv : the preprint server for biology · 2026Article
- Central nervous system lymphatic network: from the maintenance of brain homeostasis to emerging therapeutic perspectives in neurodegenerative diseases.Translational neurodegeneration · 2026Review
- The Clearance-Centered Bottleneck in Alzheimer's Disease: From Coupled Glymphatic-Lymphatic Circuits to Therapeutic Opportunities.Molecular neurobiology · 2026Review
- Artificial intelligence-based segmentation of perisinusoidal tissue along the superior sagittal sinus in human brain magnetic resonance imaging.Neuroradiology · 2026Article
- When blood hits the brain: altered glymphatic and dural lymphatic function after surface bleeds.Acta neurochirurgica · 2026Article
- Idiopathic Normal Pressure Hydrocephalus with Brain Herniation into the Arachnoid Granulation of the Lateral Lacuna of the Superior Sagittal Sinus: A Case Report.NMC case report journal · 2026Article
- Exercise timing as a potential temporal regulator of neurolymphatic physiology in neurodegenerative proteinopathies: a mechanistic framework.Frontiers in neuroscience · 2026Review
- New integrated three-interface conceptual model for clearance and immune surveillance in the human CNS.Frontiers in cell and developmental biology · 2026Review
- Structural and vascular alterations of deep cervical lymph nodes in amyloid PET-positive Alzheimer's disease patients.Cerebral circulation - cognition and behavior · 2026Article
- Meningeal lymphatics as a therapeutic target for neurodegenerative disorders.Translational neurodegeneration · 2025Review
- Development and validation of a multivariable prognostic model incorporating black-blood magnetic resonance imaging-based meningeal lymphatic remodeling to predict therapy response in non-small cell lung cancer brain metastases.Translational lung cancer research · 2025Article
- Meningeal lymphatic architecture and drainage dynamics surrounding the human middle meningeal artery.iScience · 2025Article
- Impaired meningeal lymphatic drainage correlates with headache intensity in episodic migraine.The journal of headache and pain · 2025Article
- Demonstration of chemotherapeutic-mediated changes in meningeal lymphatics in vitro, ex vivo, and in vivo.Communications biology · 2025Article
- Brain Drain for Brain Gain: Potential Applications of Robotic-assisted Lymphatic Microsurgery in the Management of Neurological Disorders.Plastic and reconstructive surgery. Global open · 2025Article
- Impairment of the intracranial lymphatic system in Parkinson's disease: a combined study of the meningeal lymphatics vessels and glymphatic system based on noninvasive neuroimaging.European journal of medical research · 2025Article
- The glymphatic system in oncology: from the perspective of a radiation oncologist.Journal of radiation research · 2025Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discoveries that cerebrospinal fluid participates in metabolic perivascular exchange with the brain and further drains solutes to meningeal lymphatic vessels have sparked a tremendous interest in translating these seminal findings from animals to humans. A potential two-way coupling between the brain extra-vascular compartment and the peripheral immune system has implications that exceed those concerning neurodegenerative diseases, but also imply that the central nervous system has pushed its immunological borders toward the periphery, where cross-talk mediated by cerebrospinal fluid may play a role in a range of neoplastic and immunological diseases. Due to its non-invasive approach, magnetic resonance imaging has typically been the preferred methodology in attempts to image the glymphatic system and meningeal lymphatics in humans. Even if flourishing, the research field is still in its cradle, and interpretations of imaging findings that topographically associate with reports from animals have yet seemed to downplay the presence of previously described anatomical constituents, particularly in the dura. In this brief review, we illuminate these challenges and assess the evidence for a glymphatic-lymphatic coupling. Finally, we provide a new perspective on how human brain and meningeal clearance function may possibly be measured in future.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.