Evidence map›Paper›PMID 38472380›Full record

ArticleEye (London, England)2024

Ultrawide-field fluorescein angiography features in patients with anterior uveitis.

Nam V Nguyen, Enny Oyeniran, Alexander Zeleny, Michelle Chen, Noha A Sherif, Eleni Konstantinou, Susan Vitale, H Nida Sen, Shilpa Kodati

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Nam V Nguyen *National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Enny Oyeniran *National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Alexander ZelenyNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Michelle ChenNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Noha A SherifNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Eleni KonstantinouNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Susan VitaleNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
H Nida SenNational Eye Institute, National Institutes of Health, Bethesda, MD, USA.
Shilpa KodatiNational Eye Institute, National Institutes of Health, Bethesda, MD, USA. shilpa.kodati@nih.gov.
National Institutes of Health · USNational Eye Institute · USUniversity of North Carolina at Chapel Hill · US

Funding

Studies of Ocular inflammation: Translational ResearchZIAEY000556 · NEI · NATIONAL EYE INSTITUTE · PI CASPI, RACHEL R. · 2017 to 2025
$11.3M
6 · The paper itself

Abstract

purposeTo evaluate the utility of ultrawide-field fluorescein angiography (UWFFA) in patients with anterior uveitis by investigating the detection of retinal vascular leakage (RVL) and the subsequent implications on disease diagnosis and management. STUDY DESIGN/MATERIALS AND

methodsPatients, who were referred to the National Eye Institute (NEI) for evaluation of anterior uveitis and underwent UWFFA imaging at the initial visit, were included in this study. The electronic medical records of eligible patients were reviewed. The UWFFA images were assessed for severity of retinal vascular leakage, presence of macular leakage, and optic disc leakage by a two-grader system, and intergrader agreement was calculated using the κ-value. Patients with altered diagnoses and management attributable to UWFFA results were noted.

resultsA total of 93 eyes of 63 patients were included in the study. Of 93 eyes, 31 (33.3%) eyes had RVL on UWFFA, with 26 (28.0%) eyes and 5 (5.4%) eyes showing mild and moderate-severe RVL, respectively. Twenty-five (26.9%) eyes showed macular leakage, and 7 (7.5%) eyes showed optic disc leakage. The κ-values ranged from 0.85 - 0.87 indicating excellent intergrader agreement. Of the 31 eyes with RVL, the diagnosis was changed to anterior/intermediate uveitis for 9 (29.0%) eyes and to panuveitis for 4 (12.9%) eyes. Systemic treatment was escalated in 5 patients.

conclusionOur results suggest that UWFFA imaging is useful in detecting subclinical posterior involvement in patients with anterior uveitis. Moreover, UWFFA results in altered diagnosis and treatment approaches in a portion of patients.

Indexed as

Fluorescein AngiographyUveitis, AnteriorAdolescentAdultAgedCapillary PermeabilityFemaleHumansMaleMiddle AgedRetinal DiseasesRetinal VesselsRetrospective StudiesYoung Adult

Identifiers

PMID38472380
PMCPMC11156897
OpenAlexW4394768503

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.