Evidence map›Paper›PMID 38472317›Full record

ArticleActa pharmacologica Sinica2024

Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling.

Yi Liu, Si-Jia Chen, Can Ai, Peng-Xia Yu, Man Fang, Hui Wang

Open access · greenAbstract read
In one paragraph

Article in Acta pharmacologica Sinica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yi Liu *Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Si-Jia Chen *Department of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Can AiDepartment of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Peng-Xia YuDepartment of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Man FangDepartment of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China.
Hui WangDepartment of Pharmacology, Wuhan University School of Basic Medical Sciences, Wuhan, 430071, China. wanghui19@whu.edu.cn.
Wuhan University · CNHubei Provincial Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Both epidemiological and animal studies suggest that adverse environment during pregnancy can change the offspring development programming, but it is difficult to achieve prenatal early warning. In this study we investigated the impact of prenatal dexamethasone exposure (PDE) on sperm quality and function of blood-testis barrier (BTB) in adult offspring and the underlying mechanisms. Pregnant rats were injected with dexamethasone (0.1, 0.2 and 0.4 mg·kg

Indexed as

Blood-Testis BarrierDexamethasonePrenatal Exposure Delayed EffectsSignal TransductionAnimalsFemaleMalePregnancyRatsRats, Sprague-DawleySertoli CellsSpermatozoaTestisTransforming Growth Factor betaDexamethasoneTransforming Growth Factor betablood-testis barrierFSTL3H3K9me2prenatal dexamethasone exposureprenatal warning markerstesticular dysplasia

Identifiers

PMID38472317
PMCPMC11130295
OpenAlexW4392698017

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.